234082-35-0Relevant articles and documents
POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS
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Page/Page column 30, (2018/07/29)
The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.
Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides
Rando, Daniela G.,Avery, Mitchell A.,Tekwani, Babu L.,Khan, Shabana I.,Ferreira, Elizabeth I.
, p. 6724 - 6731 (2008/12/22)
A series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC50 values lower than standard drugs. Brief SAR analysis revealed that substitution is important to the activity. Nitrothiophene analogues were more potent than the nitrofuran ones. This was attributed to the ability of sulfur atoms in accommodating electrons from nitro group, which facilitate its reduction and therefore the formation of free radicals lethal to parasites.
PROCESS FOR THE MANUFACTURE OF 4-FLUORO-ANTHRANILIC ACID
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Page/Page column 6, (2008/06/13)
The present invention concerns a process for preparing 4-fluoro-anthranilic acid by nitration, reduction and hydrolysis of an alkyl 3-chloro-4-fluorobenzoate.