23171-70-2Relevant articles and documents
Robust continuous-flow synthesis of deuterium-labeled ￠-nitroalcohols catalyzed by basic anion exchange resin
Cui, Sunliang,Ito, Naoya,Masuda, Hayato,Park, Kwihwan,Sajiki, Hironao,Teranishi, Wataru,Yamada, Tsuyoshi
, p. 1000 - 1006 (2020/09/22)
A practical and efficient continuous-flow system was developed for the synthesis of site-selectively deuterium-labeled ￠- nitroalcohols by using the tertiary amine-functionalized basic anion exchange resin, WA30, as a heterogeneous organocatalyst. For this system, WA30 was prepacked in a cartridge under metal-free conditions. The system was operated by pumping a solution of aldehydes or ketones, as electrophiles, and nitroalkanes in a solvent system of deuterium oxide and THF in the catalyst cartridge. Various deuterated ￠-nitroalcohols were obtained in moderate to excellent yields with high deuteration efficiencies. The continuous-flow system was applied in continuous synthesis for at least 72 h without degradation of the heterogeneous organocatalyst activity.
