229027-89-8

Basic information

• Product Name: 2-BROMO-4-FLUOROBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 1088;2-BROMO-4-FLUOROBENZYL ALCOHOL;(2-Bromo-4-fluorophenyl)methanol;2-BroMo-4-FluorobenzeneMethanol;EOS-61286
• CAS NO: 229027-89-8
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.02
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohol;Alcohols;Bromine Compounds;Fluorine Compounds
• Mol File: 229027-89-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 68-72℃
• Boiling Point: 262℃
• Flash Point: 112℃
• Appearance: Off-white/Solid
• Density: 1.658
• Vapor Pressure: 0.00555mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 2-BROMO-4-FLUOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-FLUOROBENZYL ALCOHOL(229027-89-8)
• EPA Substance Registry System: 2-BROMO-4-FLUOROBENZYL ALCOHOL(229027-89-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 229027-89-8(Hazardous Substances Data)

Usage

Uses

2-Bromo-4-fluorobenzyl alcohol, is used as an alcohol, medicine intermediate.

InChI:InChI=1/C7H6BrFO/c8-7-3-6(9)2-1-5(7)4-10/h1-3,10H,4H2

Upstream product

• 61150-57-0 2-bromo-4-fluorobenzyl bromide 
• 14044-65-6 borane-THF 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 1422-53-3 2-bromo-4-fluorotoluene 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 

Downstream Products

• 845302-00-3 2-bromo-4-fluoro-1-(methoxymethoxymethyl)benzene 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 845552-83-2 C₁₉H₂₂FNO₂ 
• 1222010-84-5 2-((2-bromo-4-fluorobenzyl)oxy)tetrahydro-2H-pyran 
• 1326343-89-8 C₁₂H₁₄BrFO 
• 1405206-42-9 (2-bromo-4-fluorobenzyl)(phenyl)sulfane 
• 1251222-82-8 2-bromo-4-fluoro-1-(methoxymethyl)benzene 
• 1613413-12-9 [4-fluoro-2-[2-(4-fluorophenyl)ethyl]phenyl]methanol 
• 1613413-08-3 [4-fluoro-2-[(E)-2-(4-fluorophenyl)ethenyl]phenyl]methanol 
• 1367455-31-9 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4-fluorobenzyl 2-tert-butoxycarbonylaminoacetate 
• 1367454-84-9 {2-amino-6-[5-fluoro-2-(4-hydroxypiperidin-1-ylmethyl)phenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-83-8 [2-amino-6-(2-diethylaminomethyl-5-fluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone 
• 1367455-83-1 [2-amino-6-(2-chloromethyl-5-fluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone 

Relevant articles and documents

NOVEL COMPOUNDS USEFUL AS POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS

The present invention provides novel poly(ADP-ribose) polymerase (PARP) inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods for the treatment, prevention and/or amelioration of PARP mediated diseases or disorders using them. In particular, the compounds described herein are useful for the treatment of carcinoma of the breast, ovarian cancer, carcinoma of the liver, carcinoma of the lung, small cell lung cancer, esophageal cancer, gall bladder cancer, pancreatic cancer and stomach cancer.

Copper-Catalyzed Aerobic Oxidative Cyclization Cascade to Construct Bridged Skeletons: Total Synthesis of (?)-Suaveoline

Based on the discovery of copper-catalyzed cyclopropanol ring-opening addition to iminium ions, an unprecedented catalytic aerobic C?H oxidation/cyclopropanol cyclization cascade using CuCl2 as the multifunctional catalyst and air as the oxidant was developed to construct the azabicyclo[3.3.1]nonane skeleton, which is widespread in natural products and medicines. Using this method, concise asymmetric total synthesis of the indole alkaloid (?)-suaveoline was achieved. This study not only provides an efficient, low-cost, and environmentally benign method for constructing such bridged frameworks, but also enriches the realm of cyclopropanol chemistry and C?H functionalization.

HETEROCYCLIC COMPOUNDS WITH AN ROR(GAMMA)T MODULATING ACTIVITY

The present invention relates to a compound that may have an ROR(gamma)t modulating activity and can thus be useful in the treatment of cancer.