228422-44-4

Basic information

• Product Name: (R)-1-benzyl-3-hydroxypropylamine
• Synonyms: (R)-1-benzyl-3-hydroxypropylamine
• CAS NO: 228422-44-4
• Molecular Weight: 165.235
• Mol File: 228422-44-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-1-benzyl-3-hydroxypropylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-benzyl-3-hydroxypropylamine(228422-44-4)
• EPA Substance Registry System: (R)-1-benzyl-3-hydroxypropylamine(228422-44-4)

Safety Data

• Hazardous Substances Data: 228422-44-4(Hazardous Substances Data)

Upstream product

• 32150-92-8 (R)-2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoyl chloride 
• 3588-64-5 (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionic acid 
• 673-06-3 D-(R)-phenylalanine 
• 866395-50-8 methyl (R)-3-phthalimido-4-phenylbutyrate 
• 866395-47-3 (R)-1-diazo-3-phthalimido-4-phenylbutan-2-one 
• 866395-52-0 N-(1-benzyl-3-hydroxy-propyl)-2-hydroxymethyl-benzamide 

Downstream Products

• 866395-24-6 (S)-1-mesyloxy-N-(benzyloxycarbonyl)-3-amino-4-phenylbutane 
• 866395-42-8 (S)-1-((R)-3-Benzyloxycarbonylamino-4-phenyl-butyl)-pyrrolidine-2-carboxylic acid 
• 866395-27-9 (2S,9R)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-phenyldecanoic acid methyl ester 
• 866395-30-4 (2S,9R,12S)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-11-oxononadecanoic acid methyl ester 
• 866395-33-7 (2S,9R,12S,19R)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-9-benzyl-19-(benzyloxycarbonylamino)-20-phenyl-11-oxoeicosanoic acid methyl ester 
• 101555-61-7 (R)-3-t-butoxycarbonylamino-4-phenylbutyric acid 
• 348184-48-5 (S)-N-(benzyloxycarbonyl)-3-amino-4-phenylbutan-1-ol 
• 177839-89-3 (R)-tert-butyl 4-hydroxy-1-phenylbutan-2-ylcarbamate 

Relevant articles and documents

Structure-driven design and synthesis of chiral dioxocyclam derivatives

Based on an analysis of previously reported structures and a potential geometry fit with substrates, a new family of chiral dioxocyclam derivatives have been designed. The synthesis of those ligands was accomplished starting from l-proline and α-d-amino acids (converted to β-amino acids) with a key step of macrocyclization reaction of amino esters. All ligands were converted into neutral copper(II) complexes (amide groups underwent deprotonation of upon treatment of ligands with copper(II) acetate). The complexes exhibit the desired shape of their active surfaces, as proved by X-ray analysis.

Precursors for the production of chiral 1,3-aminoalcohols

The disclosure describes novel precursors for the preparation of chiral 1,3-aminoalcohols. The precursors are chiral 4-hydroxycarboxamides, 4-hydroxyhydroxamic acids, or 4-hydroxyhydrazides produced from chiral gamma-lactones, which in turn are derived from 1,4-diols by stereoselective oxidation. The chiral 4-hydroxycarboxamides, 4-hydroxyhydroxamic acids, or 4-hydroxyhydrazides are converted into chiral 1,3-aminoalcohols by stereospecific rearrangement.