2275-23-2 Usage
Description
Vamidothion is a colorless crystalline organic thiophosphate substance that is readily soluble in water and most organic solvents, except aliphatic hydrocarbons. It decomposes in strong alkaline and acidic media and was formerly used as an insecticide and acaricide. However, it is no longer approved for use within the European Union.
Uses
Used in Agricultural Industry:
Vamidothion is used as a phosphorothioic insecticide for protecting apples and potatoes from pests. Its application helps in reducing damage to these crops caused by insects, ensuring better yield and quality.
Used in Cotton, Fruit, and Rice Industries:
Vamidothion is used as a systemic insecticide to control Homoptera, a family of insects that includes aphids, whiteflies, and scale insects. By targeting these pests in cotton, fruit, and rice crops, Vamidothion helps in maintaining the health and productivity of these agricultural industries.
Pharmacology
Pyriproxyfen formulations demonstrate persistent efficacy. For example, a water-based 5.3%
pyriproxyfen spot-on formulation applied to cats was
reported to completely prevent the hatching of flea eggs for
at least 46 days after treatment and continued to provide
greater than 96% control until day 60 (57). Because
pyriproxyfen is efficacious at very low concentrations, trace
amounts of the chemical, when transferred from treated
pets to their environments, are sufficient to inhibit the
development of larvae.
Metabolic pathway
Vamidothion is mainly metabolised via oxidation to its sulfoxide; further
oxidation to the corresponding sulfone has been observed in houseflies
but occurs much less readily than with other thioether-containing
organophosphates (e.g. phorate). The sulfoxide is then hydrolysed via
P-S and C-S bond cleavage to give the thiol or hydroxyl derivatives and
dimethyl phosphate and O,O-dimethyl phosphorothioate respectively.
O-Demethylation apparently occurs as a major degradation process
in plants but has not been observed in soil or in animals. N-Demethylation
and hydrolysis to the corresponding carboxylic acid, such as
occurs with dimethoate, does not apparently happen in the case of
vamidothion.
Degradation
Vamidothion is decomposed in strongly acidic or alkaline media
(PM). Barceld et al. (1993) examined the photolysis of vamidothion in
water containing 2-4% methanol and 5% acetone as a photosensitiser
irradiated by a xenon arc (suntest) lamp. Metabolites were analysed
and characterised by HPLC, thermospray MS and UV (diode array)
spectra. The main degradation product identified was vamidothion
sulfoxide (2). This product of vamidothion photolysis is shown in
Scheme 1.
Toxicity evaluation
The acute oral
LD50 for rats is 64–105 mg/kg. Inhalation LC50 (4 h) for
rats is 1.73 mg/L air. ADI is 8 μg/kg b.w.
Check Digit Verification of cas no
The CAS Registry Mumber 2275-23-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,7 and 5 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2275-23:
(6*2)+(5*2)+(4*7)+(3*5)+(2*2)+(1*3)=72
72 % 10 = 2
So 2275-23-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H18NO4PS2/c1-7(8(10)9-2)15-5-6-16-14(11,12-3)13-4/h7H,5-6H2,1-4H3,(H,9,10)