22390-99-4

Basic information

• Product Name: Benzenemethanol, 4-methyl-a-methylene-, acetate
• CAS NO: 22390-99-4
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol File: 22390-99-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-methyl-a-methylene-, acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-methyl-a-methylene-, acetate(22390-99-4)
• EPA Substance Registry System: Benzenemethanol, 4-methyl-a-methylene-, acetate(22390-99-4)

Safety Data

• Hazardous Substances Data: 22390-99-4(Hazardous Substances Data)

Upstream product

• 591-87-7 Allyl acetate 
• 122-00-9 para-methylacetophenone 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 766-97-2 4-n-methylphenylacetylene 
• 108-22-5 Isopropenyl acetate 
• 622-97-9 1-ethenyl-4-methylbenzene 

Downstream Products

• 91176-30-6 trimethyl(3-(p-tolyl)but-3-en-1-yl)silane 
• 42482-66-6 3,4,5,6-tetrahydro-2,2,6-trimethyl-6-(4-methylphenyl)-2H-pyran 
• 121194-34-1 3,3,3-trifluoro-1-(4-methylphenyl)propan-1-one 
• 1181267-64-0 2-methyl-4-oxo-4-(p-tolyl)butanenitrile 
• 122-00-9 para-methylacetophenone 

Relevant articles and documents

Visible-Light-Promoted Synthesis of α-CF2H-Substituted Ketones by Radical Difluoromethylation of Enol Acetates

An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of α-CF2H-substituted ketones has been described. Upon irradiation under blue LED with catalytic amounts of fac-Ir(ppy)3, this photocatalytic procedure employs difluoromethyltriphenylphosphonium bromide as a radical precursor. Various α-CF2H-substituted ketones are successfully created via designed systems based on the SET process. The methodology has also provided an operationally simple process with broad functional group compatibility.

Visible light induced C-H monofluoroalkylation to synthesize 1,4-unsaturated compound

We developed a method to synthesize fluorinated 1,4-unsaturated dicarbonyl compounds via photoredox catalyzed radical addition process. Commercially available ethyl bromodifluoroacetate (BrCF2CO2Et) as fluoroalkyl source, the corresponding fluoro-containing dicarbonyl compounds could be obtained in moderate to good yields.

Ag2CO3-mediated direct functionalization of alkyl nitriles: Facile synthesis of γ-ketonitriles through nitrile alkylation of enol acetates

Direct C(sp3)-H functionalization of alkyl nitriles is a low toxic and facile route to nitrile-containing compounds. In this research, the Ag2CO3-mediated nitrile methylenation of enol acetates is developed to prepare γ-ketonitriles through the direct C(sp3)-H oxidative functionalization of acetonitrile. A radical pathway is proposed, and acetonitrile serves both as solvent and CN-containing radical source.