22333-58-0Relevant articles and documents
Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines
Moreira, Caroline dos S.,Nicoletti, Caroline D.,Pinheiro, Daniel P.,de Moraes, Leonardo G. C.,Futuro, Debora O.,Ferreira, Vitor F.,Pessoa, Claudia do ó,da Rocha, David R.
, p. 2109 - 2117 (2019)
14 new naphthoquinones were prepared and tested against human cancer cell lines PC-3 (prostate), HCT-116 (colon carcinoma), SNB-19 (glioblastoma), HL-60 (leukemia) and MCF-7 (breast), and a nontumor cell line L929 (murine fibroblasts) to determine cytotoxicity with the MTT assay. 8-OH-β-lapachones (14a, 14c, 14d) presented best results, showing low IC50 values and high selectivity for HCT-116 and HL-60 tumor cells.
Synthesis of the naturally occurring naphtho- | 2,3-b | pyran-5,10-quinones α-caryopterone, dihydro-α-caryopterone and their isomers 6-hydroxy-dehydro-α-lapachone and 6-hydroxy-α-lapachone
De Oliveira,Ferreira,Soares Raslan
, p. 155 - 158 (1988)
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Effect of 9-hydroxy-α-and 7-hydroxy-β-pyran naphthoquinones on trypanosoma cruzi and structure-Activity relationship studies
Da Rocha, David R.,De Souza, Alessandra M.T.,De Souza, Ana Carolina G.,Castro, Helena C.,Rodrigues, Carlos R.,Menna-Barreto, Rubem F.S.,De Castro, Solange L.,Ferreira, Vitor F.
, p. 564 - 570 (2014/11/08)
The available treatment for the prevention and cure of Chagas disease, caused by the protozoan Trypanosoma cruzi, is still unsatisfactory. Thus, there is an urgent need to develop new drugs. In the last few years, our research group has focused on finding
