22247-87-6 Usage
Description
7-(beta-chloroethyl)guanine, also known as 7-(2-Chloroethyl)guanine, is a purine derivative with significant biological activities. It has been investigated for its potential as an inhibitor of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and as an antiprotozoal agent. The presence of the beta-chloroethyl group in its structure contributes to its unique properties and interactions with biological targets.
Uses
Used in Pharmaceutical Industry:
7-(beta-chloroethyl)guanine is used as an inhibitor for hypoxanthine-guanine phosphoribosyltransferase (HGPRT) due to its ability to interfere with the enzyme's function. This inhibition can be beneficial in the development of treatments for certain diseases and conditions where HGPRT plays a crucial role.
Additionally, 7-(beta-chloroethyl)guanine is used as an antiprotozoal agent for its potential to combat protozoan infections. This application is particularly relevant in the treatment of diseases caused by protozoan parasites, such as malaria, leishmaniasis, and trypanosomiasis.
Check Digit Verification of cas no
The CAS Registry Mumber 22247-87-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,4 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 22247-87:
(7*2)+(6*2)+(5*2)+(4*4)+(3*7)+(2*8)+(1*7)=96
96 % 10 = 6
So 22247-87-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H8ClN5O/c8-1-2-13-3-10-5-4(13)6(14)12-7(9)11-5/h3H,1-2H2,(H3,9,11,12,14)
22247-87-6Relevant articles and documents
ALKYLATION OF 6-METHYLTHIO- AND 6-BENZYLOXYGUANINE UNDER PHASE-TRANSFER CONDITIONS
Ramzaeva, N.,Alksnis, E.,Goldberg, Yu.,Lidaks, M.
, p. 3121 - 3128 (2007/10/02)
Phase-transfer-catalyzed alkylation of 6-methylthio- and 6-benzyloxyguanine followed by acid hydrolysis provides a simple procedure for the preparation of various 9- and 7-substituted guanines.
