22162-15-8

Basic information

• Product Name: Benzenemethanol, 2-methyl-4-nitro-
• Synonyms: Benzenemethanol, 2-methyl-4-nitro-;(2-Methyl-4-nitrophenyl)Methanol;2-Methyl-4-nitrobenzyl alcohol;2-methyl-4-nitrobenzenemethanol
• CAS NO: 22162-15-8
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Mol File: 22162-15-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 97-98 °C
• Boiling Point: 342.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.272
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.62±0.10(Predicted)
• CAS DataBase Reference: Benzenemethanol, 2-methyl-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2-methyl-4-nitro-(22162-15-8)
• EPA Substance Registry System: Benzenemethanol, 2-methyl-4-nitro-(22162-15-8)

Safety Data

• Hazardous Substances Data: 22162-15-8(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 2-methyl-4-nitro-, also known as p-nitro-ortho-cresol, is a chemical compound with the molecular formula C8H9NO3. It is a yellow crystalline substance that is widely used as an antibacterial and antifungal agent in various personal care products such as soaps, shampoos, and cosmetics. It works by inhibiting the growth of bacteria and fungi, making it a common ingredient in topical medications. However, the compound has been associated with potential skin irritation and allergic reactions in some individuals, leading to its restricted use in certain countries. Additionally, it is considered toxic to aquatic organisms and may have harmful effects in the environment if not properly disposed of.

Upstream product

• 1975-51-5 2-methyl-4-nitrobenzoic acid 
• 99-51-4 4-nitro-o-xylene 
• 22162-14-7 1-(bromomethyl)-2-methyl-4-nitrobenzene 

Downstream Products

• 22162-14-7 1-(bromomethyl)-2-methyl-4-nitrobenzene 
• 497851-48-6 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]-3-methylphenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 497854-65-6 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]-3-methylphenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 497849-03-3 7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]-3-methylphenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 497854-63-4 (2-methyl-4-nitrophenyl)(pyridin-2-yl)methanol 
• 497854-64-5 (4-amino-2-methylphenyl)(pyridin-2-yl)methanol 
• 72005-84-6 2-methyl-4-nitro-benzaldehyde 
• 251643-61-5 N-[2-(N,N-Dimethylamino)ethyl] 4-[N-methyl-N-(2-methyl-4-nitrobenzyloxycarbonyl)amino]phenylacetamide 
• 251643-36-4 4-[N-Methyl-N-(2-methyl-4-nitrobenzyloxycarbonyl)amino]phenylacetic acid 
• 251643-27-3 Methyl 4-[N-methyl-N-(2-methyl-4-nitrobenzyloxycarbonyl)amino]phenylacetate 

Relevant articles and documents

A highly selective fluorogenic substrate for imaging glutathione S-transferase P1: Development and cellular applicability in epigenetic studies

Pi-class glutathione S-transferase (GSTP1) is a molecular marker enzyme whose expression level is altered in various malignant tumour tissues. Herein, we report the first highly selective fluorogenic GSTP1 substrate, Ps-TG, and its membrane-permeable deri

Heterocyclic compound

本發明提供一種具有CDK8/19抑制活性之雜環化合物。本發明提供一種如下式代表之化合物(其中各代號均如本文之定義)或其鹽。 The present invention provides a heterocyclic compound possessing CDK8/19 inhibitory activity. The present invention provides a compound represented by the formula wherein each symbol is as defined herein, or a salt thereof.

BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS

β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types.