22146-58-3

Basic information

• Product Name: 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID
• Synonyms: 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID
• CAS NO: 22146-58-3
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.2096
• Mol File: 22146-58-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID(22146-58-3)
• EPA Substance Registry System: 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID(22146-58-3)

Safety Data

• Hazardous Substances Data: 22146-58-3(Hazardous Substances Data)

Upstream product

• 33105-81-6 2-amino-3,3-dimethylbutanoic acid 
• 108-24-7 acetic anhydride 
• 29671-33-8 acide chloro-2 dimethyl-3,3 butanoique 
• 1070-83-3 tert-Butylacetic acid 
• 75-36-5 acetyl chloride 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 630-19-3 pivalaldehyde 
• 92195-63-6 N-(2,2-dimethyl-1-phenylpropyl)acetamide 

Downstream Products

• 22146-59-4 (S)-2-acetylamino-3,3-dimethylbutyric acid 
• 72756-21-9 2-(benzoylamino)-3,3-dimethylbutanoic acid 
• 143005-55-4 (+/-)-2-acetylamino-3,3-dimethylbutyric acid methyl ester 
• 251988-75-7 N-[2,2-dimethyl-1-(4-methyl-benzoyl)-propyl]-acetamide 
• 26782-71-8 D-tert-leucine 
• 20859-02-3 L-tert-Leucine 
• 1274867-46-7 (Z)-N-(1-(4-(4-hydroxybenzylidene)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)-2,2-dimethylpropyl)acetamide 

Relevant articles and documents

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Preparation D at the same time-and L- uncle leucine method (by machine translation)

This invention relates to a kind of simultaneously preparing D-and L- uncle leucine method, comprising the following steps: step (1): the positive butanol and 1,1-dichloroethylene reaction, to obtain 3,3-dimethyl butanoic acid product; step (2): in the 3,3-dimethyl-butyric acid, a catalyst is added in the product, at the same time access air and chlorine, to chloropivaloyl, to obtain 2-chloro -3,3-dimethyl butanoic acid; step (3): the obtained 2-chloro -3,3-dimethyl butanoic acid for aminolysis reaction, to obtain D-, L-tert-leucine; step (4): the D-, L-tert-leucine for acetylation and acetyl chloride, with L-heat-stable to amino acid acylase split and other processing, respectively obtained L-tert-leucine and D-tert-leucine; step (5): the split recovery acetylation or chloroactic acidylated recovery D-tert-leucine for racemic, is circulated and split. The present invention uses low-cost normal butanol and 1,1-dichloroethylene as the starting material. From economic benefits speaking, the cost of this invention is substantially below that of the biological reduction method. (by machine translation)

Enzyme-assisted Preparation of D-tert.-Leucine

Optically pure D-tert.-leucine was obtained by the enzymatic hydrolysis of (±)-N-acetyl-tert. leucine chloroethyl ester after about 50% conversion, this being catalyzed by a protease from Bacillus licheniformis (Alcalase), and subsequent acidic saponification of the recovered ester. Among the methyl, ethyl, octyl, chloroethyl and trichloroethyl esters, the chloroethyl ester exhibited the highest rate of hydrolysis.