21950-36-7

Basic information

• Product Name: Adenosine, 5'-aMino-5'-deoxy-2',3'-O-(1-Methylethylidene)-
• Synonyms: Adenosine, 5'-aMino-5'-deoxy-2',3'-O-(1-Methylethylidene)-;9-((3aR,4S,6R,6aR)-6-(aMinoMethyl)-2,2-diMethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-aMine;5'-AMino-5'-deoxy-2',3'-O-isopropylidineadenosine;5'-AMino-5'-deoxy-2',3'-O-(1-Methylethylidene)-adenosine;Adenosine,5`-deoxy-2`3`-O-(1-Methylethylidene)-;5'-Amino-5'-O-(1-methylethylidene)-adenosine;9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine
• CAS NO: 21950-36-7
• Molecular Formula: C₁₃H₁₈N₆O₃
• Molecular Weight: 306.32042
• Mol File: 21950-36-7.mol
• Article Data: 39

Chemical Properties

• Melting Point: 202-203℃
• Boiling Point: 553.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.80±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.08±0.29(Predicted)
• CAS DataBase Reference: Adenosine, 5'-aMino-5'-deoxy-2',3'-O-(1-Methylethylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, 5'-aMino-5'-deoxy-2',3'-O-(1-Methylethylidene)-(21950-36-7)
• EPA Substance Registry System: Adenosine, 5'-aMino-5'-deoxy-2',3'-O-(1-Methylethylidene)-(21950-36-7)

Safety Data

• Hazardous Substances Data: 21950-36-7(Hazardous Substances Data)

Upstream product

• 24514-56-5 9-((3aR,4R,6S,6aS)-6-(chloromethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine 
• 72525-43-0 5'-O-(p-toluenesulfonyl)-2',3'-O'-isopropylideneadenosine N¹-oxide 
• 362-75-4 2',3'-isopropylidene adenosine 
• 58-61-7 adenosine 
• 40982-79-4 N⁶,N⁶-dibenzoyl-5'-O-mesyl-2',3'-O-isopropylidene adenosine 
• 40653-96-1 N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-methylsulfonyladenosine 
• 68144-26-3 5'-azido-5'-deoxy-N⁶-benzoyl-2',3'-O-isopropylidene adenosine 
• 68179-90-8 ((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl methanesulfonate 
• 5605-63-0 ((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate 
• 78111-39-4 5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine 
• 39947-04-1 N-6-benzoyl-2',3'-O-isopropylideneadenosine 
• 39947-05-2 ((3aR,4R,6R,6aR)-6-(6-benzamido-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate 
• 34245-48-2 5'-azido-5'-deoxy-2',3'-O-isopropylidene adenosine 
• 80860-44-2 2-[[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl]-2,3-dihydro-1H-isoindol-1,3-dione 

Downstream Products

• 162757-17-7 1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea 
• 100-02-7 4-nitro-phenol 
• 220579-83-9 <4-(3-<<6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro<3,4-d><1,3>dioxol-4-ylmethyl>-amino>-propyl)-phenyl>-oxoacetic acid methyl ester 
• 366454-10-6 N-[6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-N'-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-succinamide 
• 366454-11-7 Pentanedioic acid [(3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-amide (1-oxo-2,3-dihydro-1H-isoindol-4-yl)-amide 
• 901776-52-1 (S)-tert-butyl 4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)-2-(((benzyloxy)carbonyl)amino)butanoate 

Relevant articles and documents

Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase

Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'- isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichi coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.

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Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate

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