219138-08-6

Basic information

• Product Name: Z-VDVAD-AFC
• Synonyms: CASPASE-2 SUBSTRATE I, FLUOROGENIC;Z-VDVAD-AFC;Z-VAL-ASP-VAL-ALA-ASP-AFC;Z-Val-Asp-Ala-Asp-AFC;N-[(Phenylmethoxy)carbonyl]-L-valyl-L-alpha-aspartyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine
• CAS NO: 219138-08-6
• Molecular Formula: C39H45F3N6O13
• Molecular Weight: 862.8
• Mol File: 219138-08-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-VDVAD-AFC(CAS DataBase Reference)
• NIST Chemistry Reference: Z-VDVAD-AFC(219138-08-6)
• EPA Substance Registry System: Z-VDVAD-AFC(219138-08-6)

Safety Data

• Hazardous Substances Data: 219138-08-6(Hazardous Substances Data)

Usage

General Description

The chemical Z-VDVAD-AFC is a synthetic substrate commonly used in caspase assays to measure the activity of caspase-2, -3, -6, -7 and -10. It is a fluorogenic peptide substrate that is cleaved by these caspases, leading to the release of the fluorescent AFC (7-amino-4-trifluoromethylcoumarin) moiety. This release of AFC can then be measured using a fluorescence plate reader, allowing for the quantification of caspase activity. Z-VDVAD-AFC is a valuable tool for studying the role of these caspases in various biological processes, such as apoptosis and inflammation, and for screening potential caspase inhibitors.