21898-19-1 Usage
Description
Clenbuterol hydrochloride is a hydrochloride that is the monohydrochloride salt of clenbuterol, a substituted phenylethanolamine with β2 sympathomimetic activity. It is a colorless microcrystalline powder and functions as a β2-adrenergic receptor agonist, making it a potent bronchodilator.
Uses
Used in Pharmaceutical Industry:
Clenbuterol hydrochloride is used as a bronchodilator for the prevention and treatment of bronchial asthma, chronic bronchitis, and emphysema-accompanied bronchial spasms caused by bronchitis. It acts as a decongestant bronchodilator, providing relief from respiratory issues.
Used in Veterinary Medicine:
Clenbuterol hydrochloride is used as a growth promoter in farm animals due to its β-agonist properties, which can enhance muscle growth and reduce fat content.
Used in Antiasthmatic Applications:
As an antiasthmatic agent, Clenbuterol hydrochloride is utilized for its bronchodilating effects, helping to alleviate symptoms of asthma and other respiratory conditions by relaxing the smooth muscles in the airways.
Selective β2 adrenergic receptor agonist
Clenbuterol-hydrochloride exhibits as white crystalline powder. Its chemical name is hydroxymethyl tert-butanol adrenaline or 2-[(tert-butylamino) methyl]-4-amino-3, 5-dichlorobenzene methoxide salt. It is a kind of potent, selectively β2 adrenergic receptor agonists and can be used for relaxing bronchial smooth muscle for the treatment of bronchial asthma, asthmatic bronchitis and bronchitis with emphysema.
The main component of "Shouroujing" is clenbuterol. Because of its certain effects on animals such as promoting the protein synthesis of muscle, promoting lipid decomposition and reducing fat accumulation, it can cause the relative increase of lean meat content of the animal and thus improving livestock quality. Owing to this property, we also referred it as "growth promoters" and "nutrition re-dispersing agent."
In the early 1960s, it was found that it can promote the animal growth; In the 1970s, the United States had introduced it into poultry production and it has become the world's most widely used β-stimulants. However, as the substance has a strong thermal stability and biochemical stability, after animal consumption, it is capable of forming residue in organs and tissues. Upon eating pork containing clenbuterol, people can get poisoning symptoms. Thus, many countries in the world had sooner or later banned the application of β-agonists in animal husbandry. Many countries have developed detection method for monitoring β-agonists residues and clenbuterol of the feed. In 1997, our government had also banned clenbuterol for being used as feed additives.
Precautions: a minority of patients may get adverse reactions such as mild heart palpitations, tremor, and dizziness with the symptoms gradually disappear in general after the medication. Patients of hyperthyroidism, tachycardia or hypertension should be taken with caution.
Preparation: ordinary tablets, aerosols, suppositories, films agent and patches.
The above information is edited by the lookchem of Dai Xiongfeng.
Category toxic
substances
Toxicity grading
highly toxic
Acute toxicity
intraperitoneal-mouse TDL0: 2 mg/kg
Flammability and hazard characteristics
flammable with combustion cause its decomposition into toxic chloride and nitrogen oxide gases
Storage properties, warehouse
cold, ventilated and dry; store it separately from food raw materials
Veterinary Drugs and Treatments
Clenbuterol is approved for use in horses as a bronchodilator in the
management of airway obstruction, such as recurrent airway obstruction
(RAO; formerly COPD).
It has been used as a partitioning agent in food producing animals,
but its use for this purpose is banned in the USA as relay toxicity
in humans has been documented.
Check Digit Verification of cas no
The CAS Registry Mumber 21898-19-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,8,9 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21898-19:
(7*2)+(6*1)+(5*8)+(4*9)+(3*8)+(2*1)+(1*9)=131
131 % 10 = 1
So 21898-19-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H
21898-19-1Relevant articles and documents
Environment-friendly non-toxic synthesis method of clenbuterol hydrochloride
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Paragraph 0032; 0050; 0056-0059, (2020/07/21)
The invention provides an environment-friendly non-toxic synthesis method of clenbuterol hydrochloride. The synthesis method comprises the following steps: 1) preparing an intermediate 1; 2) preparingan intermediate 2; 3) preparing clenbuterol; and 4) preparing the clenbuterol hydrochloride. The synthesis method comprises the following steps: synthesizing an intermediate 1 by adopting an oxidation method; and then forming a Schiff base intermediate 2 with tert-butylamine, and then preparing clenbuterol by reduction so that the condition that an alpha-bromo-structure intermediate with genotoxicity is prepared by using liquid bromine or other brominating agents in a traditional production process is avoided, the new synthesis method is environment-friendly and non-toxic, and the clinical use risk of clenbuterol hydrochloride is effectively reduced.
Sustained release pharmaceutical plaster
-
, (2008/06/13)
A sustained release pharmaceutical plaster which is characterized in that it is a pharmaceutical preparation mainly composed of an adhesive compound layer and a supporter which supports the adhesive compound layer, inside of which there is an arrangement of hollow fibers, that have radially arranged open pores, with their tubular hollows filled with medicines.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.