21892-75-1Relevant articles and documents
In vivo metabolism of diallyl disulphide in the rat: Identification of two new metabolites
Germain,Auger,Ginies,Siess,Teyssier
, p. 1127 - 1138 (2002)
1. Diallyl disulphide (DADS), a compound formed from the organosulphur compounds present in garlic, is known for its anticarcinogenic effects in animal models. 2. The aim was to identify and analyse the metabolites produced in vivo after a single oral administration of 200mgkg-1 DADS to rats. The organic sulphur metabolites present in the stomach, liver, plasma and urine were measured by gas chromatography coupled with mass spectrometry over 15 days. 3. Data indicate that DADS is absorbed and transformed into allyl mercaptan, allyl methyl sulphide, allyl methyl sulphoxide (AMSO) and allyl methyl sulphone (AMSO2), which are detected throughout the excretion period. Overall, the highest amounts of metabolites were measured 48-72 h after the DADS administration. AMSO2 is the most abundant and persistent of these compounds. The levels of all the sulphur compounds rapidly decline within the first week after administration and disappear during the second week. Only AMSO and AMSO2 are significantly excreted in urine. 4. These potential metabolites are thought to be active in the target tissues. Our data warrant further studies to check this hypothesis.
[MoO3(2,2″–bipy)]n catalyzed oxidation of amines and sulfides
Tosi, Irene,Vurchio, Carolina,Abrantes, Marta,Gon?alves, Isabel S.,Pillinger, Martyn,Cavani, Fabrizio,Cordero, Franca M.,Brandi, Alberto
, p. 60 - 64 (2017/10/09)
The polymeric catalyst [MoO3(2,2′–bipy)]n has been employed in the oxidation of secondary amines to nitrones, and sulfides to sulfoxides or sulfones, using tert–butylhydroperoxide (TBHP) as the stoichiometric oxidant. Whereas the oxi
Oxidation of thioethers and sulfoxides with hydrogen peroxide using TS-1 as catalyst
Hutchings,Lee,McMorn,Page,Robinson,Willock,Davies,Watson,McGuire,Lee,Bethell
, p. 1523 - 1529 (2007/10/03)
A combined experimental and molecular simulation study of the oxidation of thioethers with H2O2 was conducted using titanium-containing zeolites as catalysts. Regioselectivity was investigated for the oxidation of allyl methyl thioether using TS-1 as catalyst. Only products for the oxidation of sulfur, such as sulfoxide and sulfolane, were found. Shape-selective oxidation was studied with four isomeric butyl methyl thioethers. For n-, iso-, and sec-butyl methyl thioethers, the principal product for the TS-1 catalyzed reaction was the sulfone, but that for tert-butyl methyl thioether was from partial oxidation to sulfoxide. The origin of this effect was evaluated using molecular simulations. Thioether oxidation to sulfoxide readily occurred via a non-catalyzed solution reaction, while the oxidation of sulfoxide to sulfone was only observed in the catalyzed reactions. The non-catalyzed reaction can be suppressed by conducting the catalyzed reaction in the presence of a base, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), that is too large to diffuse into the intracrystalline pore structure of TS-1. With DBU, the reaction rate with TS-1 as catalyst was much lower. The relative ratios of the sulfoxide and sulfone products can be elucidated through intramolecular steric hindrance and the shape selectivity of the zeolite. TS-1 has been used for the oxidation of alkenes, alcohols, allylic alcohols, phenols, and benzene.
