2188-68-3 Usage
Description
Lycorine hydrochloride, with the chemical formula C18H38ClNO4, is a naturally occurring alkaloid derived from the Amaryllidaceae family of plants. It is known for its potent bioactive properties, which include anti-cancer, antiviral, and circadian rhythm regulation effects. Lycorine hydrochloride has been found to arrest the cell cycle at the G2/M phase, induce apoptosis in tumor cells, inhibit human enterovirus 71 replication, and selectively inhibit human ovarian cancer cell proliferation and neovascularization.
Uses
Used in Anticancer Applications:
Lycorine hydrochloride is used as an anticancer agent for its ability to arrest the cell cycle at the G2/M phase and induce apoptosis in tumor cells. It is particularly effective against human ovarian cancer, with an IC50 value of 1.2 μM, making it a promising candidate for the development of targeted cancer therapies.
Used in Antiviral Applications:
Lycorine hydrochloride is used as an antiviral agent for its ability to inhibit human enterovirus 71 replication by blocking the elongation of the viral polyprotein during translation. This action reduces viral cytopathic effects in mice, suggesting its potential use in the development of antiviral treatments for enterovirus infections.
Used in Circadian Rhythm Regulation:
Lycorine hydrochloride is used as a circadian rhythm regulator for its dose-dependent ability to extend the circadian period length in mammalian cells by enhancing Bmal1 transcription. This property makes it a potential candidate for the development of treatments for sleep disorders and other conditions related to the disruption of the circadian rhythm.
Used in Cholesterol Metabolism Regulation:
Lycorine hydrochloride is used as a potent SREBF chaperone (SCAP) degrader, with a Kd value of 15.24 nM. It acts via an autophagy-independent lysosomal pathway, making it a potential candidate for the development of treatments targeting cholesterol metabolism and related metabolic disorders.
Biochem/physiol Actions
A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.
References
Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168
Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483
Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407
Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174
Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1
Check Digit Verification of cas no
The CAS Registry Mumber 2188-68-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,8 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2188-68:
(6*2)+(5*1)+(4*8)+(3*8)+(2*6)+(1*8)=93
93 % 10 = 3
So 2188-68-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1
