2181-19-3

Basic information

• Product Name: 4-bromo-1-azabicyclo[2.2.2]octane
• Synonyms: 4-Bromo-1-azabicyclo(2.2.2)octane; 4-Bromo-1-azabicyclo[2.2.2]octane
• CAS NO: 2181-19-3
• Molecular Formula: C₇H₁₂BrN
• Molecular Weight: 190.0809
• Mol File: 2181-19-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 201°C at 760 mmHg
• Flash Point: 75.4°C
• Density: 1.49g/cm³
• Vapor Pressure: 0.315mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 4-bromo-1-azabicyclo[2.2.2]octane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1-azabicyclo[2.2.2]octane(2181-19-3)
• EPA Substance Registry System: 4-bromo-1-azabicyclo[2.2.2]octane(2181-19-3)

Safety Data

• Hazardous Substances Data: 2181-19-3(Hazardous Substances Data)

Upstream product

• 26458-74-2 quinuclidin-4-ol 

Downstream Products

• 461648-39-5 α,α-diphenyl-1-azabicyclo[2.2.2]octane-4-methanol 
• 100-76-5 Quinuclidine 

Relevant articles and documents

Novel method for synthesizing umeclidinium bromide

The invention discloses a method for preparing an umeclidinium bromide intermediate compound as shown in a formula 3, and further discloses a synthesizing method of umeclidinium bromide. The synthesizing method effectively avoids unstable phenyl lithium with high price and toxicity, corresponding quinuclidine building reaction steps are omitted, reaction steps are greatly decreased, and reaction efficiency and yield are improved. The synthesizing method is shorter in reaction step, mild in operation condition, high in safety, low in environmental pollution and higher in yield, and a good basisis provided for industrial amplification of the umeclidinium bromide.