216870-24-5Relevant articles and documents
NEW PROCESS FOR PREPARING LORATADINE FROM A KETONE INTERMEDIATE
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Page/Page column 12, (2015/06/18)
This application is directed to a last step synthetic process for making loratadine from ketone intermediate.
Syntheses of novel piperidin-4-ylphosphinic acid, and piperidin-4-ylphosphonic acid analogues of the inhibitory neurotransmitter 4-aminobutyric acid (GABA)
Kehler, Jan,Ebert, Bjarke,Dahl, Otto,Krogsgaard-Larsen, Povl
, p. 3241 - 3243 (2007/10/03)
Piperidin-4-ylphosphinic acid, methyl(piperidin-4-yl)phosphinic acid and piperidin-4-ylphosphonic acid analogues of the GABAA agonist piperidin-4-ylcarboxylic acid (isonipecotic acid) were synthesised. The acid groups were introduced using a sequential Pudovik addition followed by a Barton deoxygenation procedure and finally followed by acidic hydrolysis. The mild and efficient procedure gave the target amino acids in good yields.