215934-32-0

Basic information

• Product Name: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate
• Synonyms: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate;Bankit;Benzeneacetic acid, 2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene)-, methyl ester, (E)-;Einecs annex I index 607-256-00-x;Hsdb 7017
• CAS NO: 215934-32-0
• Molecular Formula: C₂₂H₁₇N₃O₅
• Molecular Weight: 0
• Mol File: 215934-32-0.mol
• Article Data: 49

Chemical Properties

• Boiling Point: 581.3°C at 760 mmHg
• Flash Point: 305.3°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 1.67E-13mmHg at 25°C
• Refractive Index: 1.626
• Water Solubility: 6g/L at 20℃
• CAS DataBase Reference: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate(215934-32-0)
• EPA Substance Registry System: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate(215934-32-0)

Safety Data

• Hazard Codes: T:Toxic;;
• Statements: R23:; R50/53:
• Safety Statements: S22:; S45:; S60:; S61:
• Hazardous Substances Data: 215934-32-0(Hazardous Substances Data)

Usage

General Description

Methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy-prop-2-enoate is a chemical compound that belongs to the class of methoxypropenoates. It is a synthetic organic compound with a complex structure consisting of a methyl group attached to a 2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yl)oxyphenyl)-3-methoxyprop-2-enoate moiety. methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate may have potential applications in the pharmaceutical industry, particularly in the development of new drugs targeting specific cellular pathways or receptors. Its precise properties and uses would depend on further research and testing.

InChI:InChI=1/C22H17N3O5/c1-27-13-17(22(26)28-2)16-8-4-6-10-19(16)30-21-11-20(24-14-25-21)29-18-9-5-3-7-15(18)12-23/h3-11,13-14H,1-2H3/b17-13+

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 131860-97-4 (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate 
• 611-20-1 salicylonitrile 
• 107-21-1 ethylene glycol 
• 1193-21-1 4,6-dichloropyrimidine 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 
• 114077-42-8 (E)-3-methoxy-2-(2-hydroxyphenyl)-acrylic acid methyl ester 
• 175971-61-6 2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester 
• 40800-90-6 (E)-3-(α-methoxy)methylenebenzofuran-2(3H)-one 
• 143230-42-6 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropionic acid methyl ester 
• 74255-21-3 2-hydroxybenzonitrile sodium salt 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 77-78-1 dimethyl sulfate 
• 40800-90-6 3-(α-methoxy)methylene benzofuran-2-(3H)-ketone 

Downstream Products

• 143130-94-3 methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate 
• 240802-59-9 2-(6-hydroxypyrimidin-4-yloxy)benzonitrile 
• 1185255-09-7 (E)-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylic acid 
• 478413-45-5 2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)acetic acid methyl ester 
• 1193-24-4 4,6-pyrimidinediol 

Relevant articles and documents

Method for improving conversion rate of azoxystrobin

The invention discloses a method for improving the conversion rate of azoxystrobin. The method comprises the following steps: preparing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate; preparing o-hydroxybenzonitrile; mixing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate, o-hydroxybenzonitrile, potassium carbonate and ketene chloride according to a molar ratio of 30: 35: 50: 1.1, and dissolving the obtained mixture in dimethylformamide to obtain a mixed product; and heating the prepared mixed product, keeping the mixed product at a certain temperature, conducting filtering, carrying out reduced-pressure distillation, performing cooling, separating out crystals, carrying out filtering and washing and performing drying to obtain azoxystrobin. On the basis of the prior art, the synthesis of azoxystrobin is improved in the invention, so the yield of azoxystrobin is effectively increased, the conversion rate of the raw materials including methyl(E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate and o-hydroxybenzonitrile for azoxystrobin in the process of preparing azoxystrobin is effectively improved, and the production benefit of azoxystrobin is improved.

AN IMPROVED PROCESS FOR PREPARATION OF METHYL (2E)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE

The present invention relates to an improved processses for synthesizing preparing substituted cyanophenoxy-pyrimidinyloxy-phenyl acrylate derivatives. The present invention specifically relates to an improved process for the preparation of methyl (2E)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyacrylate having the following Formula I.

PROCESS FOR THE PREPARATION OF FUNGICIDALLY ACTIVE STROBILURIN COMPOUNDS AND INTERMEDIATES THEREOF

The present invention relates to a process for the preparation of strobilurin of compounds of Formula (I) of and its intermediates using 1,5,7-triazabicyclo[4.4.0]dec-5-ene or salts thereof, or derivatives thereof as a catalyst. The present invention provides the compounds of formula (I) in high yield and high purity.