21399-34-8

Basic information

• Product Name: (1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine
• CAS NO: 21399-34-8
• Molecular Formula: C₁₈H₂₀N₂O₂
• Molecular Weight: 296.3636
• Mol File: 21399-34-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 402.68°C at 760 mmHg
• Flash Point: 159.411°C
• Density: 1.043g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: (1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine(21399-34-8)
• EPA Substance Registry System: (1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine(21399-34-8)

Safety Data

• Hazardous Substances Data: 21399-34-8(Hazardous Substances Data)

Usage

Description

(1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine is an organic compound with the molecular formula C16H20N2O. It belongs to the class of hydrazines, which are nitrogen-containing compounds, and is a bis-hydrazine, containing two hydrazine functional groups. The presence of the (1E)-bis[1-(4-methoxyphenyl)ethylidene] groups in the molecule indicates a specific type of carbon-carbon double bond. (1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine has potential applications in organic synthesis and may exhibit interesting chemical properties due to the methoxyphenyl and ethylidene groups in its structure.

Uses

Used in Organic Synthesis:
(1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure, including the methoxyphenyl and ethylidene groups, allows it to participate in a range of chemical reactions, making it a valuable building block in the creation of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
(1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine may be used as a starting material or intermediate in the development of pharmaceutical compounds. Its nitrogen-containing structure and the presence of the hydrazine functional groups can be exploited to create new drugs with potential therapeutic effects.
Used in Chemical Research:
(1E)-bis[1-(4-methoxyphenyl)ethylidene]hydrazine can be utilized in chemical research to study the properties and reactivity of hydrazine-containing compounds. Its unique structure may provide insights into the behavior of similar compounds and contribute to the advancement of organic chemistry.

Upstream product

• 32117-52-5 1-(1-(4-methoxyphenyl)ethylidene)-2-tosylhydrazine 
• 354-48-3 1,1,1-tribromotrifluoroethane 
• 6310-14-1 4'-methoxyacetophenone hydrazone 
• 56-23-5 tetrachloromethane 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 70078-14-7 1-(1-diazoethyl)-4-methoxybenzene 

Downstream Products

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 78049-09-9 cis-1-methyl-1,2-di-p-anisylcyclopropane 
• 78049-09-9 trans-1-methyl-1,2-p-anisylcyclopropane 
• 104-93-8 p-methylanizole 
• 1712-69-2 1-isopropenyl-4-methoxybenzene 
• 104-45-0 4-n-propylanisole 
• 4132-48-3 1-methoxy-4-(1-methylethyl)benzene 
• 23263-96-9 3-methyl-5-p-methoxyphenyl-1-hydropyrazole 
• 100-66-3 methoxybenzene 
• 767-00-0 4-cyanophenol 
• 874-90-8 4-methoxybenzonitrile 
• 99-93-4 4-Hydroxyacetophenone 
• 121-97-1 4-Methoxypropiophenone 
• 108-95-2 phenol 

Relevant articles and documents

Cs2CO3-mediated decomposition of N-tosylhydrazones for the synthesis of azines under mild conditions

Abstract: A facile, environmentally and efficient Cs2CO3-mediated decomposition of N-tosylhydrazones reaction has been developed for the synthesis of functionalized azines under mild conditions. This method offers broad substrate scope, occurs as additive-free, without strong base conditions, utilizes readily available reactants, and forms products in good to high yields. Graphical Abstract: [Figure not available: see fulltext.]

Base and solvent mediated decomposition of tosylhydrazones: Highly selective synthesis of N-alkyl substituted hydrazones, dialkylidenehydrazines, and oximes

Base and solvent mediated decomposition of tosylhydrazones was studied. It was found that reaction of tosylhydrazones in CH3NO2 in the presence of 1 equiv of K2CO3 in 90 °C gave N-alkylated products in 52-96% yield. However, when the same reaction was carried out in mixed solvent of CH3NO2 and dioxane in the presence of 3 equiv of NaOH at 110 °C, dialkylidenehydrazines were obtained in moderate to high yield. If the reaction was carried out in mixed solvent of CH3NO2 and DMSO in the presence of 10 equiv of NaOH at 110 °C, CH3NO2 can act as the precursor of hydroxylamine and corresponding oximes were formed in up to 92% yield.

Catalytic olefination of carbonyl compounds. Effect of the structure of the carbonyl compound on the reaction

The mechanism of the novel reaction of catalytic olefination of carbonyl compounds was studied. The reaction involves the transformation of hydrazones of aromatic aldehydes and ketones into the corresponding dichloroalkenes and symmetrical azines by the treatment with carbon tetrachloride in the presence of CuCl as a catalyst. The stability of intermediate diazoalkanes is the main factor determining the direction of the reaction. In the case of sufficiently stable diazoalkanes, other products can be formed under the reaction conditions along with the products of catalytic olefination.