212713-08-1 Usage
Description
BIS(3,5-DI-TERT-BUTYL-4-METHOXYPHENYL)CHLOROPHOSPHINE is an organophosphorus compound characterized by its chemical structure that features two 3,5-di-tert-butyl-4-methoxyphenyl groups attached to a central phosphorus atom, with one of the phenyl groups bearing a chlorine substituent. BIS(3,5-DI-TERT-BUTYL-4-METHOXYPHENYL)CHLOROPHOSPHINE is known for its reactivity and utility in various chemical reactions and processes.
Uses
Used in Asymmetric Hydrogenation:
BIS(3,5-DI-TERT-BUTYL-4-METHOXYPHENYL)CHLOROPHOSPHINE is used as a reactant for asymmetric hydrogenation with iridium catalysts. Its unique structure allows for selective and efficient hydrogenation reactions, which are crucial in the synthesis of enantiomerically pure compounds, particularly in the pharmaceutical industry.
Used in Chemoselective Reactions:
In the field of organic chemistry, BIS(3,5-DI-TERT-BUTYL-4-METHOXYPHENYL)CHLOROPHOSPHINE is employed as a reactant for chemoselective reactions with deprotonated 2-hydroxy-3,3,N-trimethylbutanamide. This application is significant for the synthesis of complex organic molecules with specific functional groups, which can be used in various chemical and pharmaceutical applications.
Used in Synthesis of Phosphine-Containing Amino Acids:
BIS(3,5-DI-TERT-BUTYL-4-METHOXYPHENYL)CHLOROPHOSPHINE is utilized as a reactant for the synthesis of phosphine-containing amino acids. These amino acids are essential building blocks in the development of novel bioactive peptides and proteins with potential applications in medicine and biotechnology.
Used in Peptide-Based Catalyst Ligand Synthesis:
This organophosphorus compound is also used as a reactant for the synthesis of peptide-based catalyst ligands. These ligands are vital in the development of catalysts for various chemical reactions, including asymmetric catalysis, which is essential for the production of chiral compounds with specific biological activities.
Used in Palladium-Catalyzed Asymmetric Allylic Substitution Reactions:
BIS(3,5-DI-TERT-BUTYL-4-METHOXYPHENYL)CHLOROPHOSPHINE is used as a reactant for the synthesis of nonracemic phosphine-containing amino acids, which are crucial components in palladium-catalyzed asymmetric allylic substitution reactions. These reactions are vital in the preparation of chiral building blocks for the pharmaceutical and agrochemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 212713-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,2,7,1 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 212713-08:
(8*2)+(7*1)+(6*2)+(5*7)+(4*1)+(3*3)+(2*0)+(1*8)=91
91 % 10 = 1
So 212713-08-1 is a valid CAS Registry Number.
InChI:InChI=1/C30H46ClO2P/c1-27(2,3)21-15-19(16-22(25(21)32-13)28(4,5)6)34(31)20-17-23(29(7,8)9)26(33-14)24(18-20)30(10,11)12/h15-18H,1-14H3
212713-08-1Relevant articles and documents
Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H2
Tan, Xuefeng,Gao, Shuang,Zeng, Weijun,Xin, Shan,Yin, Qin,Zhang, Xumu
supporting information, p. 2024 - 2027 (2018/02/19)
A ruthenium/C3-TunePhos catalytic system has been identified for highly efficient direct reductive amination of simple ketones. The strategy makes use of ammonium acetate as the amine source and H2 as the reductant and is a user-friendly and operatively simple access to industrially relevant primary amines. Excellent enantiocontrol (>90% ee for most cases) was achieved with a wide range of alkyl aryl ketones. The practicability of this methodology has been highlighted by scalable synthesis of key intermediates of three drug molecules. Moreover, an improved synthetic route to the optimal diphosphine ligand C3-TunePhos is also presented.
