210631-68-8Relevant articles and documents
Preparation method of topramezone
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Paragraph 0031-0043, (2021/09/21)
The invention relates to a preparation method of topramezone. The method comprises: carrying out reaction on a compound I (3-[3-bromo-2-methyl-6-(methylthio)-phenyl]-4, 5-dihydroisoxazole) and a compound II (1-methyl-5-hydroxypyrazole) in the atmosphere of a copper catalyst, a ligand, an organic solvent, an alkali and a CO gas to prepare the topramezone, wherein the reaction temperature is controlled to be 25-120 DEG C, and the reaction time is 18-24 hours. The preparation method is simple and convenient to operate, the catalyst is cheap, the production cost is greatly reduced, the product yield is high, and the preparation method can be used for industrial production of topramezone.
Preparation method of topramezone
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, (2021/01/04)
The invention relates to a preparation method of topramezone. Themethod comprises the following steps of: (1) carrying out oxidation reaction on a compound 5 and an oxidant under the action of a catalyst to obtain a compound 6; (2) carrying out Grignard reaction on the compound 6, magnesium and carbon dioxide to obtain a compound 7; and (3) carrying out condensation reaction on the compound 7 and1-methyl-5-hydroxy pyrazole to obtain topramezone. The structural formula of the compound 5, the structural formula of the compound 6, the structural formula of the compound 7 are described in descriptions of the invention. The preparation method of topramezone has the advantages of few by-products, high purity and yield of topramezone, low wastewater treatment difficulty, low cost, no toxic or side effect in the production process and suitability for industrial production.
Topramezone intermediate and topramezone preparation method
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, (2020/04/06)
The invention relates to the field of organic synthesis, in particular to a topramezone intermediate and a topramezone preparation method. The topramezone preparation method comprises the following steps: 3-[3-halogen-2-methyl-6-(methylsulfonyl)phenyl]-4, 5-dihydroisoxazole and cyanide are subjected to a substitution reaction to obtain 3-[3-cyano-2-methyl-6-(methylsulfonyl)phenyl]-4, 5-dihydroisoxazole; hydrolysis reaction is performed on 3-[3-cyano-2-methyl-6-(methylsulfonyl)phenyl]-4, 5-dihydroisoxazole under the action of acid or alkali to obtain 2-methyl-3-(4, 5-dihydroisoxazole-3-yl)-4-methylsulfonyl benzoic acid; and 2-methyl-3-(4, 5-dihydroisoxazole-3-yl)-4-methylsulfonyl benzoic acid and 1-methyl-5-hydroxypyrazole are condensed and rearranged to generate topramezone. According to the topramezone intermediate and the topramezone preparation method provided by the invention, the use of an expensive palladium catalyst and a dangerous butyl lithium reagent is avoided, the yield isrelatively high, the cost is reduced, the process is simplified, the defects in the prior art are overcome, and the industrial value is achieved.