210345-25-8

Basic information

• Product Name: 4-ethoxy-1-hydroxybutan-2-one
• Synonyms: 2-butanone, 4-ethoxy-1-hydroxy-; 4-Ethoxy-1-hydroxybutan-2-one
• CAS NO: 210345-25-8
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.1577
• Mol File: 210345-25-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 214.7°C at 760 mmHg
• Flash Point: 84.6°C
• Density: 1.027g/cm³
• Vapor Pressure: 0.0337mmHg at 25°C
• Refractive Index: 1.429
• CAS DataBase Reference: 4-ethoxy-1-hydroxybutan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxy-1-hydroxybutan-2-one(210345-25-8)
• EPA Substance Registry System: 4-ethoxy-1-hydroxybutan-2-one(210345-25-8)

Safety Data

• Hazardous Substances Data: 210345-25-8(Hazardous Substances Data)

Upstream product

• 110-65-6 1,4-dihydroxybut-2-yne 
• 64-17-5 ethanol 

Relevant articles and documents

Practical synthesis of 4-hydroxy-3-oxobutylphosphonic acid and its evaluation as a bio-isosteric substrate of DHAP aldolase

An efficient four step synthesis of the title compound 4-hydroxy-3- oxobutylphosphonate (2) has been developed based on inexpensive 4-ethoxy-1- hydroxybutane-2-one using an Arbusow reaction (59% overall yield). Several dihydroxyacetone-dependent aldolases having different stereospecificities were tested for their acceptance of this phosphonomethyl substrate mimic as the aldol donor. Individual enzymes belonging to both type I (Schiff base formation) and type II (Zn2+ catalysis) mechanistic classes were found to catalyze the stereoselective addition of 2 to simple aldehydes to provide bio-isosteric analogs of sugar 1-phosphates in high yields. The lack of acceptance by specific enzymes is discussed with regard to recent protein X- ray data.