209860-88-8 Usage
Description
9ALPHA,11ALPHA-DIHYDROXY-15,15-DIFLUORO-16-PHENOXY-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, also known as Tafluprost Acid, is a derivative of Tafluprost (T004820). It is a novel prostanoid characterized by its unique chemical structure, which includes dihydroxy, difluoro, and phenoxy functional groups. This molecule is specifically designed for its application in the medical field, particularly in the treatment of glaucoma.
Uses
Used in Ophthalmology:
9ALPHA,11ALPHA-DIHYDROXY-15,15-DIFLUORO-16-PHENOXY-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID is used as a therapeutic agent for the treatment of glaucoma. It functions by reducing intraocular pressure, which is a primary risk factor for the development and progression of glaucoma. The unique chemical structure of Tafluprost Acid allows it to be effective in managing this condition, making it a valuable asset in the field of ophthalmology.
Additionally, as the first prostanoid to be released in a preservative-free formula, Tafluprost Acid offers a safer alternative for patients who may be sensitive or allergic to preservatives commonly found in eye drop formulations. This preservative-free aspect enhances patient compliance and reduces the risk of adverse reactions, further solidifying its importance in the treatment of glaucoma.
Check Digit Verification of cas no
The CAS Registry Mumber 209860-88-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,8,6 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 209860-88:
(8*2)+(7*0)+(6*9)+(5*8)+(4*6)+(3*0)+(2*8)+(1*8)=158
158 % 10 = 8
So 209860-88-8 is a valid CAS Registry Number.
209860-88-8Relevant articles and documents
Method for large-scale preparation of tafluprost
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Paragraph 0019; 0026, (2021/01/24)
The invention discloses a method for industrially preparing tafluprost. The method comprises the following steps: taking Corey lactone as an initial raw material, oxidizing, condensing, fluorinating,deprotecting, reducing, re-condensing, esterifying and r
An Asymmetric Suzuki-Miyaura Approach to Prostaglandins: Synthesis of Tafluprost
Fletcher, Stephen P.,Goetzke, F. Wieland,Ku?era, Roman
supporting information, (2020/04/09)
We report the catalytic asymmetric synthesis of Tafluprost (1), a prostaglandin analogue. This synthesis demonstrates a new approach to prostaglandins involving symmetrization and desymmetrization of a racemic precursor to control the absolute and relative stereochemistry of the cyclopentyl core. Key steps include a diastereo- and enantioselective Rh-catalyzed Suzuki-Miyaura reaction of a racemic bicyclic allyl chloride and an alkenyl boronic acid and a regio- and diastereoselective Pd-catalyzed Tsuji-Trost reaction with an enolate surrogate.
Processes for the preparation of isomer free prostaglandins
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Paragraph 0204; 0205, (2015/03/03)
Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.