20577-61-1Relevant articles and documents
Synthesis, structure and antitumor activity of a new water-soluble platinum complex, (1R,2R-cyclohexanediamine-N,N')[2-hydroxy-4-oxo-2-pentenoato(2-)-O2]p latinum(II)
Kawai,Kitano,Mutoh,Hata
, p. 357 - 361 (1993)
The reaction of dihydroxo(1R,2R-cyclohexanediamine)platinum(II) with 2,4-dioxopentanoic acid gave a water-soluble complex, (1R,2R-cyclohexanediamine-N,N')[2-hydroxy-4-oxo-2-pentenoato(2-)-O2]p latinum(II). The structure of the complex was determined by X-ray crystal analysis. The data indicated a chelation of the acetylacetonato part of 2,4-dioxo-pentanoic acid to platinum(II). The complex showed moderate antitumor activity against murine leukemia L1210 in mice (T/C = 195% at a dose of 200 mg/kg) and high activity against cisplatin-resistant L1210 leukemia (T/C = 275% at a dose of 25 mg/kg).
With anti-tumor activity of the 3-substituted pyrazole-5-amide compound and use thereof (by machine translation)
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Paragraph 0077; 0078; 0079, (2016/10/09)
The invention belongs to the field of medical technology, relates to a sulfenyl class with anti-tumor activity of the compounds, in particular to a thio-containing the 3-substituted pyrazole-5-amide compounds, and its pharmaceutically acceptable salt, hydrate, and the compound is a pharmaceutical composition of the active ingredient, the preparation and and its histone deacetylase inhibitor for the treatment and/or use in the prevention of cancer. The compounds of general formula I to shows, and its pharmaceutically acceptable salt, hydrate structure is as follows :? wherein R 1, R 2 such as the claim and the specification. (by machine translation)
SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
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Paragraph 0138, (2015/10/28)
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.