205751-56-0Relevant articles and documents
Glycosidopyrroles, part 2. Acyclic derivatives: 1-(1,3-dihydroxy-2- propoxy)methylpyrroles as potential antiviral agents
Almerico,Diana,Barraja,Dattolo
, p. 667 - 672 (2007/10/03)
The series of 1-(1,3-dihydroxy-2-propoxy)methylpyrroles 2a-o were prepared in good overall yields according to Scheme I. When evaluated for antiviral activity against HIV-1, only compounds of the triphenyl series (R3=NH2, N3, Br) were found to inhibit the HIV-1 replication at concentrations that were very not cytotoxic for MT-4 cells, with selectivity index 1.5-9.3. None of these compounds showed antibacterial or antifungal activity.