202865-73-4 Usage
Description
2-BROMO-4-FLUORO-1-IODOBENZENE is a halogenated aromatic compound characterized by the presence of bromine, fluorine, and iodine atoms attached to a benzene ring. It is a clear colorless to light yellow liquid with unique chemical properties that make it suitable for various applications in organic synthesis and chemical research.
Uses
Used in Organic Synthesis:
2-BROMO-4-FLUORO-1-IODOBENZENE is used as a key intermediate in the synthesis of tetrasubstituted alkenes. Its unique combination of halogen atoms allows for stereoand regioselective stannyllithiation of diarylacetylenes, which is crucial for the formation of complex organic molecules with specific structural features.
Used in Chemical Research:
Due to its distinct chemical properties and reactivity, 2-BROMO-4-FLUORO-1-IODOBENZENE is also employed in chemical research for studying the effects of halogen substitution on the benzene ring. This can provide valuable insights into the development of new synthetic methods, reaction mechanisms, and the design of novel compounds with specific properties and applications.
Used in Pharmaceutical Industry:
2-BROMO-4-FLUORO-1-IODOBENZENE can be utilized in the pharmaceutical industry as a building block for the development of new drugs with potential therapeutic applications. Its unique structure and reactivity can be exploited to create novel drug candidates with improved pharmacological properties, such as enhanced potency, selectivity, and reduced side effects.
Used in Material Science:
In the field of material science, 2-BROMO-4-FLUORO-1-IODOBENZENE can be employed in the design and synthesis of new materials with specific properties, such as optoelectronic materials, polymers, and coatings. Its halogenated nature can influence the electronic, thermal, and mechanical properties of these materials, making them suitable for various high-tech applications.
Check Digit Verification of cas no
The CAS Registry Mumber 202865-73-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,8,6 and 5 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 202865-73:
(8*2)+(7*0)+(6*2)+(5*8)+(4*6)+(3*5)+(2*7)+(1*3)=124
124 % 10 = 4
So 202865-73-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrFI/c7-5-3-4(8)1-2-6(5)9/h1-3H
202865-73-4Relevant articles and documents
Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles
Durka, Krzysztof,Laudy, Agnieszka E.,Charzewski, ?ukasz,Urban, Mateusz,St?pień, Karolina,Tyski, Stefan,Krzy?ko, Krystiana A.,Luliński, Sergiusz
supporting information, p. 11 - 24 (2019/03/26)
A series of 22 benzosiloxaboroles, silicon analogues of strong antimicrobial agents - benzoxaboroles, have been synthesized and tested against β-lactamases KPC- and pAmpC-producing strains of Gram-negative rods. Comprehensive structural-property relationship studies supported by molecular modelling as well as biological studies reveal that 6-B(OH)2-substituted derivative 27 strongly inhibits the activity of cephalosporinases (chromosomally encoded AmpC and plasmid encoded CMY-2) and KPC carbapenemases. It also shows strong ability to inhibit growth of the strains producing KPC-3 when combined with meropenem. In addition, halogen-substituted (mono-, di- or tetra-) benzosiloxaboroles demonstrate high antifungal activity (MIC 1.56–6.25 mg/L) against C. tropicalis, C. guilliermondii and S. cerevisiae. The highest activity against pathogenic yeasts (C. albicans, C. krusei and C. parapsilosis - MICs 12.5 mg/L) and against Gram-positive cocci (S. aureus and E. faecalis - 6.25 mg/L and 25 mg/L respectively) was displayed by 6,7-dichloro-substituted benzosiloxaborole. The studied systems exhibit low cytotoxity toward human lung fibroblasts.
