19935-75-2

Basic information

• Product Name: Benzene, 1-(1-chloroethyl)-4-nitro-
• CAS NO: 19935-75-2
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Mol File: 19935-75-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1-chloroethyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1-chloroethyl)-4-nitro-(19935-75-2)
• EPA Substance Registry System: Benzene, 1-(1-chloroethyl)-4-nitro-(19935-75-2)

Safety Data

• Hazardous Substances Data: 19935-75-2(Hazardous Substances Data)

Upstream product

• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 
• 100-19-6 (4-nitrophenyl)ethanone 
• 100-12-9 4-ethylnitrobenzene 
• 41780-82-9 4-methyl-N'-(1-(4-nitrophenyl)ethylidene)benzenesulfonohydrazide 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 603-35-0 triphenylphosphine 
• 594-27-4 tetramethylstannane 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 
• 83966-40-9 C₈H₈NO₂ 
• 62558-04-7 p-(1,2-Dimethyl-2-nitropropyl)-nitrobenzol 
• 100-19-6 (4-nitrophenyl)ethanone 
• 24904-79-8 meso-2,3-di-p-nitrophenylbutane 
• 10061-22-0 α-(2,4-dinitrophenyl)ethyl nitrate 
• 132886-51-2 trans-4.4'-Dinitro-α.α'-dimethyl-stilben 
• 19759-27-4 4-(α-acetoxyethyl)-1-nitrobenzene 
• 120702-26-3 1-(4-nitrophenyl)ethyl methyl ether 
• 72511-19-4 5-methyl-3,5-bis-(4-nitro-phenyl)-4,5-dihydro-isoxazole 2-oxide 
• 72511-20-7 5-methyl-3,5-bis-(4-nitro-phenyl)-4,5-dihydro-isoxazole 

Relevant articles and documents

A New Method for Generating Trichlorotitanium(IV) Ester Homoenolates. Direct Tin-Titanium Exchange

Treatment of the β-tri-n-butylstannyl derivatives of esters with titanium tetrachloride in dichloromethane effects tin-titanium exchange to generate trichlorotitanium(IV) homoenolate derivatives of the esters, which may then be used in further reaction with electrophiles.

Thiourea-Mediated Halogenation of Alcohols

The halogenation of alcohols under mild conditions expedited by the presence of substoichiometric amounts of thiourea additives is presented. The amount of thiourea added dictates the pathway of the reaction, which may diverge from the desired halogenation reaction toward oxidation of the alcohol, in the absence of thiourea, or toward starting material recovery when excess thiourea is used. Both bromination and chlorination were highly efficient for primary, secondary, tertiary, and benzyl alcohols and tolerate a broad range of functional groups. Detailed electron paramagnetic resonance (EPR) studies, isotopic labeling, and other control experiments suggest a radical-based mechanism. The fact that the reaction is carried out at ambient conditions, uses ubiquitous and inexpensive reagents, boasts a wide scope, and can be made highly atom economic, makes this new methodology a very appealing option for this archetypical organic reaction.

Regioselective Synthesis of Vinyl Halides, Vinyl Sulfones, and Alkynes: A Tandem Intermolecular Nucleophilic and Electrophilic Vinylation of Tosylhydrazones

A diazo species is trapped in an intermolecular fashion by two independent ion species in tandem at the carbene center to install an electrophile and a nucleophile on the same carbon. This metal-free concept, which is unprecedented, has been illustrated by regioselective synthesis of a variety of vinyl halides, vinyl sulfones, and alkyne derivatives. (Chemical Equation Presented).