19900-84-6Relevant articles and documents
Unexpected formation of 3-methylsulfanyl-2-phenyl-2-cyclobutenone in the reaction of 1,3-dilithio-2-propynylbenzene with methoxymethyl isothiocyanate
Tarasova,Brandsma,Nedolya,Ushakov,Dmitrieva,Koroteeva
, p. 131 - 132 (2004)
-
Stereoselective synthesis of N-[(1Z)-2-methoxy-1-methylsulfanylbuta-1,3- dien-1-yl]formamide
Tarasova,Nedolya,Volostnykh,Albanov,Trofimov
, p. 1891 - 1893 (2011)
-
Process for preparing cephalosporin derivatives
-
, (2008/06/13)
A process for the manufacture of a cephalosporin derivative of the formula I STR1 in which X is sulphur, oxygen or sulphinyl; R1 is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R2 is hydrogen or 1-6C alkyl; R3 is hydrogen or 1-6C alkyl; and the pharmaceutically-acceptable acid-addition and base-addition salts thereof, characterized by cyclization of a compound of the formula II: STR2 or a derivative thereof in which the carbonyl group is masked, or an acid-addition salt thereof, in which R4 and R5 individually have one of the values for R2 and R3, R6 is a nitrogen-protecting group and R7 is hydrogen or any one of the cephalosporin 3-carboxylic acid protecting groups known in the art; whereafter when the product from the cyclization retains the protecting group R7 (when R7 is other than hydrogen) the protecting group R7 is replaced by hydrogen by conventional means; and whereafter when the compound of the formula I is obtained in the form of the free base or salt, and a pharmaceutically-acceptable salt or free base respectively is required, any necessary conversion between free base and salt is carried out by conventional means.