198895-61-3

Basic information

• Product Name: N-BOC-4-(2-ETHOXYCARBONYL-VINYL)-PIPERIDINE
• Synonyms: N-BOC-4-(2-ETHOXYCARBONYL-VINYL)-PIPERIDINE;N-Boc-(2-Ethoxycarbonyl-vinyl)-piperidine);Ethyl E-N-BOC-Piperidin-4-ylacrylate;(E)-tert-butyl 4-(3-ethoxy-3-oxoprop-1-en-1-yl)piperidine-1-carboxylate
• CAS NO: 198895-61-3
• Molecular Formula: C₁₅H₂₅NO₄
• Molecular Weight: 283.3633
• Mol File: 198895-61-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 362.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.102±0.06 g/cm3(Predicted)
• PKA: -2.16±0.40(Predicted)
• CAS DataBase Reference: N-BOC-4-(2-ETHOXYCARBONYL-VINYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-4-(2-ETHOXYCARBONYL-VINYL)-PIPERIDINE(198895-61-3)
• EPA Substance Registry System: N-BOC-4-(2-ETHOXYCARBONYL-VINYL)-PIPERIDINE(198895-61-3)

Safety Data

• Hazardous Substances Data: 198895-61-3(Hazardous Substances Data)

Usage

General Description

N-BOC-4-(2-ethoxycarbonyl-vinyl)-piperidine is a chemical compound used in organic synthesis. It is a derivative of piperidine, which is a six-membered heterocyclic ring containing one nitrogen atom. The compound contains a BOC (tert-butoxycarbonyl) protecting group, which is commonly used to protect amine groups in organic synthesis. The ethoxycarbonyl-vinyl substituent on the piperidine ring makes this compound useful for constructing complex molecules through various synthetic reactions. N-BOC-4-(2-ethoxycarbonyl-vinyl)-piperidine is often used as a precursor for the synthesis of pharmaceuticals, agrochemicals, and other biologically active compounds.

Upstream product

• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 141-78-6 ethyl acetate 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 206446-47-1 4-(prop-2-en-1-yl)-1-t-butoxycarbonylpiperidine 
• 301232-45-1 tert-butyl 4-(3-ethoxy-3-oxopropyl)-1-piperidinecarboxylate 

Relevant articles and documents

Diastereoselective Three-Component 3,4-Amino Oxygenation of 1,3-Dienes Catalyzed by a Cationic Heptamethylindenyl Rhodium(III) Complex

The direct oxyamination of olefins is a compelling tool to rapidly access β-amino alcohols-a privileged motif ubiquitous in natural products, pharmaceuticals and agrochemicals. Although a variety of expedient methods are established for simple alkenes, selective amino oxygenation of 1,3-dienes is less explored. Within this context, methods for the oxyamination of 1,3-dienes that are selective for the internal position remain unprecedented. We herein report a modular three-component approach to perform an internal and highly diastereoselective amino oxygenation of 1,3-dienes catalyzed by a cationic heptamethylindenyl (Ind*) Rh(III) complex.

ANTIMICROBIAL COMPOUNDS AND METHODS

The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.

Biphilic organophosphorus catalysis: Regioselective reductive transposition of allylic bromides via PIII/PV redox cycling

We report that a regioselective reductive transposition of primary allylic bromides is catalyzed by a biphilic organophosphorus (phosphetane) catalyst. Spectroscopic evidence supports the formation of a pentacoordinate (σ5-P) hydridophosphorane as a key reactive intermediate. Kinetics experiments and computational modeling are consistent with a unimolecular decomposition of the σ5-P hydridophosphorane via a concerted cyclic transition structure that delivers the observed allylic transposition and completes a novel PIII/PV redox catalytic cycle. These results broaden the growing repertoire of reactions catalyzed within the PIII/PV redox couple and suggest additional opportunities for organophosphorus catalysis in a biphilic mode.