197855-65-5 Usage
Description
Z-PHE-DL-ALA-FLUOROMETHYLKETONE, also known as Z-FA-FMK, is a potent and irreversible inhibitor of cysteine proteases such as cathepsins B, L, and S, cruzain, and papain. It selectively inhibits effector caspases-2, -3, -6, and -7 without affecting the initiator caspases-8 and -10. Additionally, Z-FA-FMK has the ability to modulate infections caused by certain bacteria, parasites, and viruses, making it a versatile compound for both cellular and in vivo applications.
Uses
Used in Pharmaceutical Industry:
Z-PHE-DL-ALA-FLUOROMETHYLKETONE is used as a therapeutic agent for the inhibition of cysteine proteases, which play a crucial role in various diseases and disorders. Its ability to selectively target effector caspases without affecting initiator caspases makes it a promising candidate for the development of targeted therapies.
Used in Research and Development:
Z-FA-FMK is used as a research tool for studying the function and regulation of cysteine proteases and caspases in cellular processes. Its irreversible inhibition property allows researchers to investigate the specific roles of these enzymes in various biological pathways.
Used in Antimicrobial Applications:
Z-PHE-DL-ALA-FLUOROMETHYLKETONE is used as an antimicrobial agent to modulate infections caused by certain bacteria, parasites, and viruses. Its ability to inhibit essential proteases in these pathogens can help in the development of novel treatments for infectious diseases.
Used in Drug Delivery Systems:
To enhance the bioavailability and therapeutic outcomes of Z-FA-FMK, various drug delivery systems can be employed. These systems can improve the compound's delivery to target cells and tissues, potentially increasing its efficacy and reducing side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 197855-65-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,8,5 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 197855-65:
(8*1)+(7*9)+(6*7)+(5*8)+(4*5)+(3*5)+(2*6)+(1*5)=205
205 % 10 = 5
So 197855-65-5 is a valid CAS Registry Number.
197855-65-5Relevant articles and documents
α Amino fluoro ketones
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, (2008/06/13)
Novel α amino fluoro ketones, a method of their synthesis and a method for irreversibly inhibiting proteases is disclosed.
