19763-90-7

Basic information

• Product Name: 3,4-Dichlorophenylhydrazine hydrochloride
• Synonyms: 1-(3,4-DICHLOROPHENYL)HYDRAZINE HYDROCHLORIDE;3,4-DICHLOROPHENYLHYDRAZINE HCL;3,4-DICHLOROPHENYLHYDRAZINE HYDROCHLORIDE;3,4-Dichoropheynylhydrazine hydrochloride;(3,4-dichlorophenyl)hydrazine monohydrochloride;3,4-DICHLOROPHENYLHYDRAZINE HYDROCHLORID E, TECH., 90%;3,4-Dichlorophenylhydrazine hydrochloride 97%;3,4-DICHLOROPHENYLHYDRAZINE HYDROCHLORIDE, 98+%
• CAS NO: 19763-90-7
• Molecular Formula: C₆H₆Cl₂N₂*ClH
• Molecular Weight: 213.49
• EINECS: 243-278-0
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine;API intermediates;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 19763-90-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 230 °C (dec.)(lit.)
• Boiling Point: 288.3 °C at 760 mmHg
• Flash Point: 128.2 °C
• Appearance: white to light yellow crystal powder
• Density: 1.475 g/cm³
• Vapor Pressure: 0.00236mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• BRN: 3703934
• CAS DataBase Reference: 3,4-Dichlorophenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dichlorophenylhydrazine hydrochloride(19763-90-7)
• EPA Substance Registry System: 3,4-Dichlorophenylhydrazine hydrochloride(19763-90-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39-36/37/39-22-24/25
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 19763-90-7(Hazardous Substances Data)

Usage

Description

3,4-Dichlorophenylhydrazine hydrochloride is an organic compound with the chemical formula C6H6Cl2N2·HCl. It is a white to light yellow crystalline powder that is commonly used in the synthesis of various chemical compounds.

Uses

Used in Chemical Synthesis:
3,4-Dichlorophenylhydrazine hydrochloride is used as a synthetic intermediate for the preparation of various chemical compounds. It serves as a building block in the production of different organic molecules, contributing to the development of new materials and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,4-Dichlorophenylhydrazine hydrochloride is used as a key component in the synthesis of certain drugs. Its reactivity and structural properties make it a valuable precursor for the development of new medications with potential therapeutic applications.
Used in Research and Development:
3,4-Dichlorophenylhydrazine hydrochloride is also utilized in research and development settings, where it is employed to study the properties and reactions of various organic compounds. Its use in this context aids in the advancement of scientific knowledge and the discovery of novel chemical processes and products.

InChI:InChI=1/C6H6Cl2N2.ClH/c7-5-2-1-4(10-9)3-6(5)8;/h1-3,10H,9H2;1H

Upstream product

• 95-76-1 m,p-dichloroaniline 

Downstream Products

• 76606-68-3 2-(3,4-dichloro-phenyl)-5-methyl-2H-pyrazol-3-ylamine 
• 77635-69-9 N-(3,4-Dichloro-phenyl)-N'-[1-(4-ethoxy-phenyl)-eth-(E)-ylidene]-hydrazine 
• 120163-40-8 5-amino-1-(3,4-dichlorophenyl)-3-methyl-4-nitrosopyrazole 
• 120163-42-0 5-(3,4-Dichloro-phenyl)-7-methyl-5H-pyrazolo[4,3-c][1,2,5]oxadiazin-3-one 
• 663180-95-8 2-(1-(3,4-dichlorophenyl)-5-hydroxy-3-(pyridin-3-yl)-1H-pyrazol-4-yl)ethyl acetate 
• 663181-14-4 C₂₀H₁₃Cl₂N₃O₂S 
• 71311-18-7 phenylpyruvic acid 3,4-dichlorophenylhydrazone 
• 66000-42-8 1-(3,4-dichlorophenyl)-3-amino-2-pyrazoline 
• 13123-99-4 2-acetyl-1-(3,4-dichlorophenyl)hydrazine 

Relevant articles and documents

Synthesis method of bixafen

The invention relates to a synthesis method of bixafen. The method comprises the steps that firstly, 3,4-dichloroaniline is prepared into 3,4-dichloro phenylhydrazine hydrochloride through a reductionagent, then air is introduced into the 3,4-dichloro phenylhydrazine hydrochloride under an alkaline environment, the 3,4-dichloro phenylhydrazine hydrochloride and para-fluoroaniline are subjected tooxidative coupling for obtaining an intermediate 3',4'-dichloro-5-fluorine-2-benzidine, and finally the intermediate and 1-methyl-3-difluoro methyl-4-parazole formyl chloride are subjected to an amidation reaction for preparing the bixafen. According to the adopted technology, the reaction conditions are mild and easy to control, operation is easily and conveniently conducted, the product is easyto purify, and the product can be obtained directly through recrystallization. The control method for intermediates in all steps is simple and accurate, the product yield is high, the atom economy isgood, complex aftertreatment of an old method is avoided, and the method has great competitive advantages and high industry production utilization value. Meanwhile, application of raw materials, withhigh dangerousness, such as butyllithium is avoided, generation of a large amount of solid waste of tarry substances is avoided, the content of the three wastes is extremely low, and the method accords with the concept of environment-friendly chemistry.

Preparation method of Eltrombopag

The invention discloses a preparation method of Eltrombopag. The chemical name of Eltrombopag is 3-{(2Z)-2-[1-(3,4-xylyl)-3-methyl-5-oxo-1,5-dihydro-4H-parazole-4-ylidene]diazanyl}-2-hydroxy-3-biphenylcarboxylic acid-2-aminoethanol salt. The process of the preparation technique of the preparation method of Eltrombopag is simple, materials are easy to obtain, and the preparation method of Eltrombopag is cost-efficient and environment-friendly, can help realize industrialization, can promote the economic and technological development of the Eltrombopag active pharmaceutical ingredient, reduce the production cost, and is suitable for mass production.

Indole synthesis by rhodium(III)-catalyzed hydrazine-directed C-H activation: Redox-neutral and traceless by N-N bond cleavage

Fishing for complements! There is an alternative to the useful Fischer indole synthesis. The new method utilizes the same retrosynthetic disconnection but is based on a RhIII-catalyzed directed C-H activation step and a successive coupling with alkynes. Copyright