197250-70-7Relevant articles and documents
DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF
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Page/Page column 46, (2012/07/28)
Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.
Desymmetrization of bicyclo[3.3.0]octane-3,7-dione by the Schmidt reaction: An easy synthesis of tecomanine
Vidari, Giovanni,Tripolini, Marco,Novella, Pietro,Allegrucci, Patrizio,Garlaschelli, Luigi
, p. 2893 - 2903 (2007/10/03)
The C(2v) symmetry of cis-bicyclo[3.3.0]octane-3,7-dione 1 was altered by a selective Schmidt reaction to give the 3-azabicyclo[4.3.0]nonane building block 3b which was employed in a short synthesis of (±)-tecomanine 4. Asymmetric Schmidt reaction on 1, employing (2S,4R)-2-azido-4-hydroxypentane 14 as a chiral inducer, showed encouraging levels of enantiotopic methylene group stereodifferentiation.