196078-30-5

Basic information

• Product Name: Pramlintide acetate
• Synonyms: AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE;pramlintide acetate;pramlintide acetate hydrate;Pramlintide Acetate, Amylin Rat;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;Tripo-aMylin Acetate Hydrate
• CAS NO: 196078-30-5
• Molecular Formula: C173H273N51O56S2
• Molecular Weight: 4027.46
• Product Categories: Peptide;Amino Acids & Derivatives;Bases & Related Reagents;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 196078-30-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Acetic Acid (Slightly), DMSO (Slightly)
• CAS DataBase Reference: Pramlintide acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Pramlintide acetate(196078-30-5)
• EPA Substance Registry System: Pramlintide acetate(196078-30-5)

Safety Data

• Hazardous Substances Data: 196078-30-5(Hazardous Substances Data)

Usage

Description

Pramlintide acetate is an injectable human amylin analog that has been developed for the treatment of both type 1 and type 2 diabetes, in conjunction with insulin. It is a 37-amino acid peptide with modifications that improve solubility and eliminate aggregation, making it a stable synthetic analog suitable for pharmaceutical use. Pramlintide acetate mimics the mechanism of action of amylin, a neurohormone cosecreted with insulin from pancreatic β cells, and is involved in glucose homeostasis.

Uses

Used in Diabetes Treatment:
Pramlintide acetate is used as an adjunct therapy for insulin-dependent diabetes, particularly for type 1 and type 2 diabetes. It helps in lowering postprandial glucose levels by inhibiting glucagon and restraining the vagus-mediated rate of gastric emptying, which slows intestinal carbohydrate absorption. Additionally, it induces postprandial satiety, resulting in weight loss in patients with type 2 diabetes.
Used in Pharmaceutical Industry:
Pramlintide acetate is used as an active pharmaceutical ingredient in the development of drugs for diabetes management. Its brand name is Symlin (Amylin), and it is a white solid with specific chemical properties that make it suitable for pharmaceutical applications.
Please note that Pramlintide acetate is contraindicated in patients with gastroparesis, those taking drugs that alter gastrointestinal motility or slow down the intestinal absorption of nutrients, and patients with hypoglycemic tendencies. The most commonly reported adverse events include nausea, vomiting, anorexia, headache, abdominal pain, fatigue, dizziness, coughing, and pharyngitis.

Clinical Use

Pramlintide acetate is a synthetic analogue of amylin (a 37-peptide) with proline substitutions at residues 25, 28, and 29. These substitutions change its physical properties such that it is commercially available for SC injection. When pramlintide is used in combination with insulin, it slows gastric emptying, lowers blood glucose levels after meals, and affords a feeling of fullness that leads to decreased caloric intake and the potential for weight loss. Pramlintide has been approved for use in adults with type I or type II diabetes as an adjunct along with insulin. The dose is quite different for type I (15–60 μg SC before meals) and type II diabetes (60–120 μg). The drug should be refrigerated before opening and may be kept at room temperature for up to 28 days after opening.

InChI:InChI=1/C171H269N51O53S2/c1-21-81(12)130(163(268)207-110(56-78(6)7)169(274)222-53-33-42-118(222)170(275)221-52-32-41-117(221)160(265)219-135(89(20)230)167(272)206-109(66-125(180)238)151(256)212-128(79(8)9)161(266)186-68-126(239)192-111(70-223)154(259)203-107(64-123(178)236)152(257)218-134(88(19)229)166(271)195-98(136(181)241)57-92-43-45-94(231)46-44-92)214-159(264)116-40-31-51-220(116)127(240)69-187-141(246)101(58-90-34-24-22-25-35-90)199-148(253)105(62-121(176)234)201-149(254)106(63-122(177)235)202-155(260)112(71-224)209-156(261)113(72-225)208-146(251)103(60-93-67-184-75-188-93)205-162(267)129(80(10)11)213-150(255)100(55-77(4)5)198-145(250)102(59-91-36-26-23-27-37-91)200-147(252)104(61-120(175)233)196-137(242)82(13)189-144(249)99(54-76(2)3)197-142(247)96(39-30-50-185-171(182)183)193-143(248)97(47-48-119(174)232)194-165(270)132(86(17)227)215-138(243)83(14)190-157(262)114(73-276)211-168(273)133(87(18)228)216-139(244)84(15)191-164(269)131(85(16)226)217-153(258)108(65-124(179)237)204-158(263)115(74-277)210-140(2