193954-28-8 Usage
Description
Fmoc-L-beta-homophenylalanine, also known as N-(9-fluorenylmethoxycarbonyl)-L-beta-homophenylalanine, is a synthetic amino acid derivative that plays a crucial role in the field of peptide synthesis. It is a white powder with specific chemical properties that make it an essential component in the production of high-quality peptides.
Uses
Used in Pharmaceutical Industry:
Fmoc-L-beta-homophenylalanine is used as a building block for the synthesis of various peptides, which are essential in the development of new drugs and therapeutic agents. Its incorporation into peptide structures allows for the creation of molecules with specific biological activities, targeting a wide range of diseases and conditions.
Used in Research and Development:
In the field of research and development, Fmoc-L-beta-homophenylalanine is utilized as a key component in the synthesis of novel peptide-based compounds. Its unique properties enable the design and creation of peptides with tailored characteristics, making it a valuable tool for exploring new therapeutic strategies and understanding the underlying mechanisms of various biological processes.
Used in Peptide Synthesis:
Fmoc-L-beta-homophenylalanine is used as a protected amino acid in solid-phase peptide synthesis (SPPS). The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a protecting group for the amino acid's side chain, allowing for the stepwise addition of other amino acids to form the desired peptide sequence. This method is widely employed in the production of high-quality peptides for various applications, including drug development, diagnostics, and research.
Check Digit Verification of cas no
The CAS Registry Mumber 193954-28-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,3,9,5 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 193954-28:
(8*1)+(7*9)+(6*3)+(5*9)+(4*5)+(3*4)+(2*2)+(1*8)=178
178 % 10 = 8
So 193954-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C25H23NO4/c27-24(28)15-18(14-17-8-2-1-3-9-17)26-25(29)30-16-23-21-12-6-4-10-19(21)20-11-5-7-13-22(20)23/h1-13,18,23H,14-16H2,(H,26,29)(H,27,28)/t18-/m1/s1
193954-28-8Relevant articles and documents
Solid-phase synthesis of a β-dodecapeptide with seven functionalized side chains and CD-spectroscopic evidence for a dramatic structural switch when going from water to methanol solution
Schreiber, Juerg V.,Seebach, Dieter
, p. 3139 - 3152 (2000)
An all-β3-dodecapeptide with a protected N-terminal thiol-anchoring group and with seven side chains has been synthesized in multi-mg amounts by the manual solid-phase technique, applying Fmoc methodology and the Wang resin. The sequence is β-H
Synthesis of Fmoc-/Boc-/Z-β-amino acids via Arndt-Eistert homologation of Fmoc-/Boc-/Z-α-amino acids employing BOP and PyBOP
Vasanthakumar,Babu, V. V. Suresh
, p. 1691 - 1695 (2007/10/03)
A simple and efficient protocol for Arndt-Eistert chain homologation of Fmoc-/Boc-/Z-α-amino acids using BOP or PyBOP as a coupling agent to the corresponding β-amino acids, synthesizing the key intermediate α-diazoketones as crystalline solids in good yield is described.
Syntheses and CD-spectroscopic investigations of longer-chain β-peptides: Preparation by solid-phase couplings of single amino acids, dipeptides, and tripeptides
Arvidsson, Per I.,Frackenpohl, Jens,Seebach, Dieter
, p. 1522 - 1553 (2007/10/03)
The synthesis and CD-spectroscopic analysis of eleven water-soluble β-peptides composed of all-β3 or alternating β2- and β3-amino acids is described. Different approaches for the efficient syntheses of longer-chain β-pepti