1928-76-3

Basic information

• Product Name: 9-BENZYL-6-CHLORO-9H-PURINE
• Synonyms: 9-BENZYL-6-CHLORO-9H-PURINE;6-CHLORO-9-BENZYLPURINE;9-Benyl-6-chloro-9H-purine;6-chloro-9-(phenylmethyl)purine;9-(benzyl)-6-chloro-purine
• CAS NO: 1928-76-3
• Molecular Formula: C₁₂H₉ClN₄
• Molecular Weight: 244.68
• Product Categories: Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides
• Mol File: 1928-76-3.mol
• Article Data: 37

Chemical Properties

• Melting Point: 86-87°C
• Boiling Point: 441 °C at 760 mmHg
• Flash Point: 220.5 °C
• Appearance: Off-white solid
• Density: 1.4 g/cm³
• Vapor Pressure: 5.64E-08mmHg at 25°C
• Refractive Index: 1.706
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 9-BENZYL-6-CHLORO-9H-PURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 9-BENZYL-6-CHLORO-9H-PURINE(1928-76-3)
• EPA Substance Registry System: 9-BENZYL-6-CHLORO-9H-PURINE(1928-76-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 1928-76-3(Hazardous Substances Data)

Usage

Description

9-Benzyl-6-chloro-9H-purine is an off-white solid that serves as a valuable intermediate in the synthesis of 1-substituted adenines, which are essential components in various chemical and pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
9-Benzyl-6-chloro-9H-purine is used as a key intermediate for the synthesis of 1-substituted adenines, which are crucial in the development of various pharmaceutical compounds. These adenine derivatives are known to have significant biological activities, making them important in the creation of new drugs and therapies.
Used in Chemical Industry:
In the chemical industry, 9-benzyl-6-chloro-9H-purine is utilized as a versatile building block for the synthesis of a wide range of chemical compounds. Its unique structure allows for further functionalization and modification, enabling the production of various specialty chemicals and materials with specific properties and applications.

Synthesis Reference(s)

The Journal of Organic Chemistry, 34, p. 1170, 1969 DOI: 10.1021/jo01256a103

InChI:InChI=1/C12H9ClN4/c13-11-10-12(15-7-14-11)17(8-16-10)6-9-4-2-1-3-5-9/h1-5,7-8H,6H2

Upstream product

• 4261-14-7 9-benzyl-9H-purin-6-ylamine 
• 100-39-0 benzyl bromide 
• 87-42-3 6-chloropurine 
• 100-44-7 benzyl chloride 
• 87-42-3 6-chloro-7H-purine 
• 100-51-6 benzyl alcohol 
• 15948-97-7 N⁴-benzyl-6-chloropyrimidine-4,5-diamine 
• 122-51-0 orthoformic acid triethyl ester 
• 108-88-3 toluene 
• 14013-11-7 9-benzyl-6-hypoxanthine 
• 100-46-9 benzylamine 
• 3815-69-8 5-amino-1-(phenylmethyl)-1H-imidazole-4-carboxamide 
• 1258274-70-2 9-benzyl-6-chloro-7,8-dihydropurine 
• 66224-66-6 adenine 

Downstream Products

• 125486-38-6 9-Benzyl-6-(pyridin-3-ylmethoxy)-9H-purine 
• 83135-02-8 9-benzyl-6-phenyl-9H-purine 
• 83135-05-1 9-benzyl-6-(4-methoxyphenyl)-9H-purine 
• 112088-98-9 (9-Benzyl-9H-purin-6-yl)-cyclopentyl-methyl-amine 
• 108160-17-4 Propan-2-one O-(9-benzyl-9H-purin-6-yl)-oxime 
• 160516-02-9 9-benzyl-6-vinyl-9H-purine 
• 160516-13-2 9-benzyl-6-methyl-9H-purine 
• 81060-73-3 methyl-(9-benzyl-9H-purin-6-yl)amine 
• 160516-03-0 9-benzyl-6-(α-ethoxyvinyl)purine 
• 112088-96-7 6-(Ethylmethylamino)-9-benzyl-9H-purine 
• 112089-01-7 6-(2-Hydroxyethylamino)-9-benzyl-9H-purine 
• 108160-11-8 9-benzyl-6-(prop-2-ynyloxy)-9H-purine 
• 6332-42-9 9-benzyl-6-dimethylamino-9H-purine 
• 129918-42-9 9-benzyl-6-(isopropylamino)purine 

Relevant articles and documents

The alkylation of 6-chloropurine with alcohols by Mitsunobu reaction

A general procedure has been developed for the preparation of 9-alkylated adenines by the Mitsunobu reaction between 6-chloropurine and several alcohols, followed by the replacement of the chlorine with ammonia. A lesser amount of the 7-alkylpurines was also obtained, irrespective of the alcohol used.

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Regioselective alkylation reaction of purines under microwave irradiation

The alkylation of purines which is generally carried out after anion formation by treatment with a base and alkyl halide is complicated and in the best cases, mixtures of N-alkylated compounds are obtained. Purine derivatives can be acquired from alkylati

Purine-ring-containing benzene sulfonamide chalcone derivative and preparation and application methods thereof

The invention discloses a purine-ring-containing benzene sulfonamide chalcone derivative and preparation and application methods thereof. The purine-ring-containing benzene sulfonamide chalcone derivative has a formula (I) shown as below, in which R1 is 4-oxymethyl, 4-tert-butyl, 4-methyl, 4-flouride, 4-bromide, 2-methyl, 2-fluoride, 2-chloride, 2-bromide and hydrogen atom and R2 is methyl, ethyland benzyl. The purine-ring-containing benzene sulfonamide chalcone derivative can inhibit tobacco mosaic virus, cucumber mosaic virus, potato Y virus and southern rice black-streaked dwarf virus.