19241-35-1

Basic information

• Product Name: 3-CHLORO-2-METHYLPHENYL ISOTHIOCYANATE
• Synonyms: AKOS BBS-00000579;3-CHLORO-2-METHYLPHENYL ISOTHIOCYANATE;1-CHLORO-3-ISOTHIOCYANATO-2-METHYLBENZENE;Benzene, 1-chloro-3-isothiocyanato-2-methyl-;3-Chloro-o-tolyl ester Isothiocyanic acid,3-Chloro-2-methylphenyl isothiocyanate;3-Chloro-2-methylphenyl isothiocyanate ,97%;3-Chloro-o-tolyl ester Isothiocyanic acid;3-Chloro-2-methylphenyl isothiocyanate ,93%
• CAS NO: 19241-35-1
• Molecular Formula: C₈H₆ClNS
• Molecular Weight: 183.66
• Mol File: 19241-35-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 290.6 °C at 760 mmHg
• Flash Point: 129.6 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.00356mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 3-CHLORO-2-METHYLPHENYL ISOTHIOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-METHYLPHENYL ISOTHIOCYANATE(19241-35-1)
• EPA Substance Registry System: 3-CHLORO-2-METHYLPHENYL ISOTHIOCYANATE(19241-35-1)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2810
• Hazardous Substances Data: 19241-35-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C8H6ClNS/c1-6-7(9)3-2-4-8(6)10-5-11/h2-4H,1H3

Upstream product

• 463-71-8 thiophosgene 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 30198-50-6 (3-Chloro-2-methyl-phenyl)-dithiocarbamic acid methyl ester 
• 14501-92-9 N,N-dimethyl-N_⁽¹⁾-(3-chloro-2-methylphenyl)thiourea 
• 6259-40-1 3-chloro-2-methyl-aniline; hydrochloride 

Downstream Products

• 108534-45-8 2-Thio-3-(3'-chloro-2'-methylphenyl)-6,8-dibromo-4-(3H)-quinazolinone 
• 187866-79-1 2-[3-(3-chloro-2-methylphenyl)-thioureido]-acetamide 
• 108534-07-2 2-(3-Amino-propylsulfanyl)-6,8-dibromo-3-(3-chloro-2-methyl-phenyl)-3H-quinazolin-4-one 
• 118449-23-3 7-Chloro-3-(3-chloro-2-methyl-phenyl)-2-(3-dimethylamino-propylsulfanyl)-3H-quinazolin-4-one 

Relevant articles and documents

Double three bromo 1,3-di-pyridine salt-based propane and its preparation method, method of use, recovery method and application

The invention discloses a double tribromo 1,3-bipyridine onium salt dimethylmethane, and a preparation method, an application method, a recovery method and application thereof. The preparation method comprises the following steps: dissolving 1,3-bipyridine onium salt dimethylmethane by using water, and then adding potassium bromide; adding potassium peroxymonosulfate sulfate compound brine solution to prepare a clear solution after dissolving potassium bromide, and then stirring and reacting at -10 to 0 DEG C until solid is separated out; separating out solid, so as to obtain the double tribromo 1,3-bipyridine onium salt dimethylmethane. The product can be used for preparing isothiocyanate, aromatic thiourea or acetanilide. The preparation method disclosed by the invention is mild in condition, and simple to operate the reaction process, and raw materials are easily available. The double tribromo 1,3-bipyridine onium salt dimethylmethane not only can be used as a brominating reagent, but also can be used as organic synthesis intermediates, meanwhile, the reaction efficiency is improved, and the double tribromo 1,3-bipyridine onium salt dimethylmethane is convenient to recover and can be recycled.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors

The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.