1910-41-4 Usage
Description
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-1,5-dihydrobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentoxy]-hydroxyphosphoryl] hydrogen phosphate is a complex organic molecule that integrates a purine base, a sugar molecule, and a phosphate group. This molecule plays a significant role in biological processes, particularly in the synthesis of DNA and RNA.
Uses
Used in Pharmaceutical Industry:
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-1,5-dihydrobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentoxy]-hydroxyphosphoryl] hydrogen phosphate is used as an active pharmaceutical ingredient for the development of drugs targeting DNA and RNA synthesis, potentially useful in the treatment of various diseases related to nucleic acid metabolism.
Used in Biotechnology Industry:
In the biotechnology sector, this molecule can be utilized as a key component in the creation of novel bioactive compounds or as a building block for the synthesis of more complex molecules with specific biological activities.
Used in Research and Development:
This chemical is also valuable in research and development settings, where it can be employed to study the mechanisms of DNA and RNA synthesis, as well as to develop new methods for the manipulation of genetic material.
Used in Diagnostics:
As a component involved in nucleic acid synthesis, this molecule may also find applications in the diagnostics industry, particularly in the development of tests that detect or measure abnormalities in DNA and RNA synthesis pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 1910-41-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,1 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1910-41:
(6*1)+(5*9)+(4*1)+(3*0)+(2*4)+(1*1)=64
64 % 10 = 4
So 1910-41-4 is a valid CAS Registry Number.
InChI:InChI=1/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1
1910-41-4Relevant articles and documents
Catalytic reduction of redox-active co-factors and proteins by dihydrogen with Sephadex supported platinum clusters as catalysts
Bhaduri, Sumit,Sharma, Krishna
, p. 207 - 208 (1996)
The platinum carbonyl cluster [Pt15(CO)30]2-, anchored onto QAE-SEPHADEX anion exchanger, is an effective catalyst for the reduction of flavin co-factors, lipoamide dehydrogenase and CytCox.
Methylene Homologues of Artemisone: An Unexpected Structure–Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins
Wu, Yuet,Wu, Ronald Wai Kung,Cheu, Kwan Wing,Williams, Ian D.,Krishna, Sanjeev,Slavic, Ksenija,Gravett, Andrew M.,Liu, Wai M.,Wong, Ho Ning,Haynes, Richard K.
, p. 1469 - 1479 (2016/07/16)
We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O- and N-glycosides into more stable C-glycosides that may possess enhanced biological activities and stabilities. Dihydroartemisinin was converted into 10β-cyano-10-deoxyartemisinin that was hydrolyzed to the α-primary amide. Reduction of the β-cyanide and the α-amide provided the respective methylamine epimers that upon treatment with divinyl sulfone gave the β- and α-methylene homologues, respectively, of artemisone. Surprisingly, the compounds were less active in vitro than artemisone against P. falciparum and displayed no appreciable activity against A549, HCT116, and MCF7 tumor cell lines. This loss in activity may be rationalized in terms of one model for the mechanism of action of artemisinins, namely the cofactor model, wherein the presence of a leaving group at C10 assists in driving hydride transfer from reduced flavin cofactors to the peroxide during perturbation of intracellular redox homeostasis by artemisinins. It is noted that the carba analogue of artemether is less active in vitro than the O-glycoside parent toward P. falciparum, although extrapolation of such activity differences to other artemisinins at this stage is not possible. However, literature data coupled with the leaving group rationale suggest that artemisinins bearing an amino group attached directly to C10 are optimal compounds.