18920-63-3

Basic information

• Product Name: vitamin E
• Synonyms: vitamin E
• CAS NO: 18920-63-3
• Molecular Weight: 430.715
• Mol File: 18920-63-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: vitamin E(CAS DataBase Reference)
• NIST Chemistry Reference: vitamin E(18920-63-3)
• EPA Substance Registry System: vitamin E(18920-63-3)

Safety Data

• Hazardous Substances Data: 18920-63-3(Hazardous Substances Data)

Upstream product

• 1169860-40-5 C₃₉H₅₅ClO₅ 
• 108-24-7 acetic anhydride 
• 17081-92-4 1-bromo-3,7,11-trimethyldodecane 
• 53101-49-8 (R)-trolox 
• 188416-16-2 (R)-(+)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol 
• 479353-40-7 (R)-[3,4-dihydro-6-benzyloxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl]methyl trifluoromethane-sulfonate 
• 6750-34-1 3,7,11-trimethyldodecyl alcohol 
• 59-02-9 vitamin E 
• 110-82-7 cyclohexane 
• 10191-41-0 (+/-)-α-tocopherol 
• 16825-16-4 (6R,10R)-6,10,14-trimethylpentadecan-2-one 
• 150-86-7 phytol 
• 82299-54-5 2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide 
• 4537-09-1 1,4-dimethoxy-2,3,5-trimethyl-benzene 

Downstream Products

• 1406-70-8 (all-rac)-α-tocopheryl acetate 
• 16676-75-8 DL-α-tocopherol nicotinate 
• 87291-70-1 DL-α-Tocopheryl phosphate dianilide 
• 54165-54-7 2S,4'R,8'R-α-tocopheryl acetate 

Relevant articles and documents

Highly stereoselective construction of the C2 stereocentre of α-tocopherol (Vitamin E) by asymmetric addition of Grignard reagents to ketones

Tertiary alcohol precursors of both C2 diastereoisomers of α-tocopherol were prepared in three ways by our recently reported asymmetric Grignard synthesis. The versatility of Grignard chemistry inherent in its three-way disconnection was exploited to allow the synthesis of three product grades: 77:23 dr (5 steps), 81:19 dr (5 steps) and 96:4 dr (7 steps, one gram scale) from readily available and abundant starting materials. The products were converted to their respective α-tocopherols in 3 steps, which allowed a definitive re-assignment of their absolute configurations.

SEPARATION OF CHIRAL ISOMERS BY SFC

The present invention relates to the field of separating chiral isomers from each other. Particularly, it relates to the field of separating of chiral isomers of chromane or chromene compounds, particularly tocopherols, 3,4-dehydro-tocopherols and tocotrienols, as well as the protected forms thereof. It has been found that the use of supercritical carbon dioxide as mobile phase combined with the very specific chiral phase as stationary phase leads to a very efficient separation of the individual chiral isomers. As the method is very efficient and fast combined with advantageous in view of ecology it is of big industrial interest.

Process of separating chiral isomers of chroman compounds and their derivatives and precursors

The present invention relates to a process of separating chiral isomers of chroman compounds, particularly tocopherols and tocotrienols as well as the esters and intermediates thereof. It has been found that this process allows a separation of the desired isomer with a higher yield and enables the use of the non-desired isomers in a very efficient way. Said process is particularly useful when implemented in an industrial process. Furthermore, it has been found that this process allows using isomer mixtures as they result from traditional industrial synthesis.