186828-50-2 Usage
General Description
2-(Bromodifluoromethyl)-1,3-benzoxazole, also known as BDFBO, is a chemical compound with the molecular formula C8H4BrF2NO. It is a benzoxazole derivative with a difluoromethyl bromide group attached to the 2-position of the benzoxazole ring. BDFBO is a versatile building block in organic synthesis and serves as a valuable intermediate for the preparation of various pharmaceutical compounds and agrochemicals. 2-(Bromodifluoromethyl)-1,3-benzoxazole has gained attention in the field of medicinal chemistry due to its potential as a pharmacological agent for the treatment of various diseases. Furthermore, BDFBO has also been studied for its use in the development of novel materials and in the production of fluorescent probes for biological imaging applications.
Check Digit Verification of cas no
The CAS Registry Mumber 186828-50-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,8,2 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 186828-50:
(8*1)+(7*8)+(6*6)+(5*8)+(4*2)+(3*8)+(2*5)+(1*0)=182
182 % 10 = 2
So 186828-50-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H4BrF2NO/c9-8(10,11)7-12-5-3-1-2-4-6(5)13-7/h1-4H
186828-50-2Relevant articles and documents
A facile preparation of 2-bromodifluoromethyl benzo-1,3-diazoles and its application in the synthesis of gem-difluoromethylene linked aryl ether compounds
Jiang, Haizhen,Yuan, Shijie,Cai, Yeshan,Wan, Wen,Zhu, Shizheng,Hao, Jian
experimental part, p. 167 - 170 (2012/02/04)
A facile preparation of 2-bromodifluoromethyl benzo-1,3-diazoles as novel CF2Br-containing heterocyclic building blocks has been developed through a one-pot process of reaction of 2-OH, 2-SH, or 2-NH2 substituted aniline with bromodifluoroacetic acid in the presence of 3 molar equivalents of CBr4 and Ph3P in refluxing toluene. 2-Bromodifluoromethyl benzo-1,3-thiazole (2b) was successfully utilized in the preparation of gem-difluoromethylene linked aryl ether compounds through the reaction with phenolates or thiophenolate in DMF in good yields.
