18640-58-9 Usage
Description
4'-BROMO-3'-NITROACETOPHENONE, also known as an electron-deficient acetophenone derivative, is a white to slightly yellow amorphous powder. It is a chemical compound that has a unique structure and properties, making it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
4'-BROMO-3'-NITROACETOPHENONE is used as an intermediate for the synthesis of various pharmaceutical compounds. Its electron-deficient nature allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of organic chemistry, 4'-BROMO-3'-NITROACETOPHENONE is used as a building block for the synthesis of various organic compounds. Its unique structure enables chemists to create a wide range of molecules with diverse properties and potential applications.
Used in Research and Development:
4'-BROMO-3'-NITROACETOPHENONE is also utilized in research and development laboratories for studying its chemical properties and potential applications. Its electron-deficient nature makes it an interesting subject for exploring new reactions and understanding its reactivity with other molecules.
Used in Material Science:
In the field of material science, 4'-BROMO-3'-NITROACETOPHENONE can be used as a component in the development of new materials with specific properties. Its unique structure and chemical properties may contribute to the creation of materials with enhanced performance in various applications, such as electronics, coatings, or adhesives.
Check Digit Verification of cas no
The CAS Registry Mumber 18640-58-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,4 and 0 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18640-58:
(7*1)+(6*8)+(5*6)+(4*4)+(3*0)+(2*5)+(1*8)=119
119 % 10 = 9
So 18640-58-9 is a valid CAS Registry Number.
18640-58-9Relevant articles and documents
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships
Zhang, Shao-Lin,Yang, Zheng,Hu, Xiaohui,Tam, Kin Yip
supporting information, p. 3441 - 3445 (2018/09/29)
Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.
SUBSTITUTED BICYCLIC HCV INHIBITORS
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Page/Page column 37-38, (2010/11/03)
Provided herein are compounds, pharmaceutical compositions and combination therapies for treatment of hepatitis C.
Substituted alkylaryl ketones and methods of use as herbicides
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, (2008/06/13)
Ring and side chain substituted alkylaryl ketones are useful in controlling the growth of germinating and seedling weed grasses and germinating and seedling broadleaf weeds.
