184845-43-0 Usage
Description
1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE, also known as NNC 05-2090 Hydrochloride, is a chemical compound with a complex structure derived from carbazole and piperidinol. It is characterized by its ability to selectively inhibit GABA uptake, particularly targeting BGT-1 (mGAT-2) transporters.
Uses
Used in Pharmaceutical Industry:
1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE is used as a GABA uptake inhibitor for its selective action on BGT-1 (mGAT-2) transporters. This property makes it a potential candidate for the development of medications targeting neurological disorders and conditions related to the GABAergic system, such as epilepsy, anxiety, and depression.
Used in Research Applications:
In the field of neuroscience and pharmacology, 1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE serves as a valuable research tool for studying the role of GABA transporters in various physiological and pathological processes. Its selective inhibition of BGT-1 (mGAT-2) transporters can help researchers better understand the mechanisms underlying GABAergic neurotransmission and develop more targeted therapies for related conditions.
Biological Activity
GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (K i values are 1.4, 15, 19 and 41 μ M for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α 1 - and D 2 -receptors (IC 50 values are 266 and 1632 nM respectively).
Check Digit Verification of cas no
The CAS Registry Mumber 184845-43-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,8,4 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 184845-43:
(8*1)+(7*8)+(6*4)+(5*8)+(4*4)+(3*5)+(2*4)+(1*3)=170
170 % 10 = 0
So 184845-43-0 is a valid CAS Registry Number.
InChI:InChI=1/C27H30N2O2.ClH/c1-31-26-14-7-4-11-23(26)27(30)15-19-28(20-16-27)17-8-18-29-24-12-5-2-9-21(24)22-10-3-6-13-25(22)29;/h2-7,9-14,30H,8,15-20H2,1H3;1H
184845-43-0Relevant articles and documents
Carbazolypiperines as GABA uptake inhibitors
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, (2008/06/13)
PCT No. PCT/DK96/00199 Sec. 371 Date Oct. 21, 1997 Sec. 102(e) Date Oct. 21, 1997 PCT Filed May 1, 1996 PCT Pub. No. WO96/34863 PCT Pub. Date Nov. 7, 1996A compound of formula (I). The present invention relates to thereutically active carbazole derivatives, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the inhibition of GABA uptake via the GAT-4 subtype carrier.
