184765-38-6

Basic information

• Product Name: 2-Propenoic acid, 2-cyano-3-phenyl-, 2-methylpropyl ester
• CAS NO: 184765-38-6
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.279
• Mol File: 184765-38-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-cyano-3-phenyl-, 2-methylpropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-cyano-3-phenyl-, 2-methylpropyl ester(184765-38-6)
• EPA Substance Registry System: 2-Propenoic acid, 2-cyano-3-phenyl-, 2-methylpropyl ester(184765-38-6)

Safety Data

• Hazardous Substances Data: 184765-38-6(Hazardous Substances Data)

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 1011-92-3 2-cyano-3-phenylacrylic acid 

Relevant articles and documents

One-pot esterification and amide formation via acid-catalyzed dehydration and ritter reactions

Esterification of carboxylic acid is achieved using acetonitrile as a water trap. Water liberated during esterification is consumed in cyanide hydrolysis, thereby driving the esterification to completion. Substrates having carboxylic acid and nitrile groups undergo intramolecular dehydration and rehydration to amido esters in the absence of acetonitrile. Cyano acids also undergo esterification and Ritter reaction in one pot when excess alcohol is used. For the first time, we have observed an interesting Ritter reaction of primary alcohols, leading to ester amide product in one pot. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]