183320-51-6 Usage
Description
OSI-420, also known as Desmethyl Erlotinib or CP-473420, is an active metabolite of erlotinib, an orally active EGFR tyrosine kinase inhibitor. It exhibits potent inhibitory effects on human EGFR and EGFR autophosphorylation in tumor cells, with an IC50 of 2 and 20 nM, respectively.
Uses
Used in Pharmaceutical Industry:
OSI-420 is used as an anticancer agent for targeting the epidermal growth factor receptor (EGFR) in tumor cells. Its potent inhibition of EGFR and EGFR autophosphorylation makes it a valuable compound in the development of cancer treatments.
Used in Biological Research:
OSI-420 is used as a research tool for studying the effects of cytochrome P450 3A on the pharmacokinetic interaction between erlotinib and docetaxel in rats. This application helps in understanding the drug metabolism and potential interactions, which is crucial for the development of effective cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 183320-51-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,3,2 and 0 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 183320-51:
(8*1)+(7*8)+(6*3)+(5*3)+(4*2)+(3*0)+(2*5)+(1*1)=116
116 % 10 = 6
So 183320-51-6 is a valid CAS Registry Number.
