183209-26-9

Basic information

• Product Name: Benzene, 1-bromo-2-isocyano- (9CI)
• Synonyms: Benzene, 1-bromo-2-isocyano- (9CI)
• CAS NO: 183209-26-9
• Molecular Formula: C₇H₄BrN
• Molecular Weight: 182.01736
• Product Categories: ISONITRITE
• Mol File: 183209-26-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzene, 1-bromo-2-isocyano- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-2-isocyano- (9CI)(183209-26-9)
• EPA Substance Registry System: Benzene, 1-bromo-2-isocyano- (9CI)(183209-26-9)

Safety Data

• Hazardous Substances Data: 183209-26-9(Hazardous Substances Data)

Upstream product

• 10113-38-9 N-(2-bromophenyl)formamide 
• 615-36-1 2-bromoaniline 

Downstream Products

• 309737-83-5 1-(2-bromophenyl)-1H-tetrazole 

Relevant articles and documents

Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds

Direct reaction of isocyanides with some sulfenic-acid-generating sulfoxides led to the effective formation of the corresponding thiocarbamic acid S-esters in good to high yields. A multicomponent reaction involving isocyanide, sulfoxide, and a suitable nucleophile has also been developed, providing ready access to a diverse range of sulfur-containing compounds, including isothioureas, carbonimidothioic acid esters, and carboximidothioic acid esters.

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.

Synthesis of selenazolopyridine derivatives with capability to induce apoptosis in human breast carcinoma MCF-7 cells through scavenge of intracellular ROS

A series of selenazolopyridine derivatives have been synthesized and characterized by X-ray diffraction, high resolution NMR and Mass spectrum. The in vitro anticancer activities of the synthetic compounds were screened against a panel of human cancer cell lines, human breast carcinoma MCF-7 cells, human liver carcinoma HepG2 cells and L02 normal cell line by MTT assay. By analyzing the structure-activity relationship among the synthetic compounds, it was found that 2-(phenylamino) selenazolo [5,4-b] pyridine, (PSeD, 7) had higher growth inhibitory effect on MCF-7 cells. The intracellular mechanism of cell death was evaluated by flow cytometric analysis and ROS assay, which revealed that PSeD could induce MCF-7 cells apoptosis by scavenging intracellular ROS. Taken together, we regard PSeD as an antioxidant which could inhibit cancer cell growth through induction of apoptosis.