18292-63-2 Usage
Description
1-(p-bromobenzoyl)aziridine, also known as p-bromobenzoylaziridine, is a chemical compound characterized by the molecular formula C10H8BrNO. It is a reactive aziridine derivative featuring a bromobenzoyl substituent attached to the aziridine ring. 1-(p-bromobenzoyl)aziridine is recognized for its unique reactivity and structural properties, which make it a valuable asset in various scientific and industrial applications. However, due to its potential toxicity and reactivity, it should be handled with caution and in accordance with proper safety protocols.
Uses
Used in Organic Synthesis:
1-(p-bromobenzoyl)aziridine is utilized as a key building block in the synthesis of a wide range of pharmaceuticals and agrochemicals. Its application in this industry is due to its ability to form carbon-carbon and carbon-nitrogen bonds, which are crucial in the creation of complex organic molecules.
Used in Materials Science:
In the field of materials science, 1-(p-bromobenzoyl)aziridine is employed as a versatile reagent. Its unique reactivity and structural properties have garnered interest for potential applications in developing new materials with enhanced properties.
Check Digit Verification of cas no
The CAS Registry Mumber 18292-63-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,2,9 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 18292-63:
(7*1)+(6*8)+(5*2)+(4*9)+(3*2)+(2*6)+(1*3)=122
122 % 10 = 2
So 18292-63-2 is a valid CAS Registry Number.
18292-63-2Relevant articles and documents
Effect of Distortion on the Hydrolytic Reactivity of Amides. 2. N-Pyramidalization: Decomposition of N-Benzoylaziridines in Aqueous Media
Slebocka-Tilk, H.,Brown, R. S.
, p. 805 - 808 (2007/10/02)
The decomposition of para-substituted N-benzoylaziridines (H, OCH3, NO2, Br) in buffered aqueous media is studied at 25 deg C as a function of pH in order to assess the effect of N-pyramidalization on the hydrolytic reactivity of the amide bond.Overall, the reaction shows three dominant terms: OH- and H2O attack on the neutral form and H2O attack on the protonated form of the amide.In base, the exclusive reaction is rate-limiting and irreversible attack of OH- on the C=O unit leading to normal hydrolytic products.This is shown by the first-order dependence on -> from pH 8 to 14 of the hydrolysis rate and by the fact that ca. 50percent 18O-enriched amide recovered from the hydrolysis medium as a function of time shows no 18O loss.Relative to N,N-dimethylbenzamide (kOH-25 deg C = 6.0 * 10-6 M-1 s-1), N-benzoylaziridine is ca. 200 000-fold more susceptible to OH- attack (kOH-25 deg C = 1.1 M-1 s-1).The kOH- terms follow a ?ρ relationship with ρ = 1.68.In acid, the products are not the expected hydrolytic ones of benzoic acid and aziridine.Rather, exclusive ring opening occurs to give p-X-C6H4C(=O)NHCH2CH2OX.In acetate buffers, product analysis by 1H NMR indicates that the ring-opened material consists of alcohol and acetate (X = H and C(=O)CH3).
