182815-44-7

Basic information

• Product Name: Colesevelam
• Synonyms: Colesevelam;Colesevelam HCL;2-Propen-1-amine polymer with (chloromethyl)oxirane, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride hydrochloride;Colesevelam hydrochloride;Colesevelam and Colesevelam Hydrochloride;COLESEVALAM;colesevelam hcl API
• CAS NO: 182815-44-7
• Molecular Formula: C31H67Cl3N4O
• Molecular Weight: 618.24888
• EINECS: 1806241-263-5
• Product Categories: Pharmaceutical intermediate;ZEFAZONE
• Mol File: 182815-44-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Colesevelam(CAS DataBase Reference)
• NIST Chemistry Reference: Colesevelam(182815-44-7)
• EPA Substance Registry System: Colesevelam(182815-44-7)

Safety Data

• Hazardous Substances Data: 182815-44-7(Hazardous Substances Data)

Usage

Description

Colesevelam, also known as Colesevelam Hydrochloride or Welchol, is a non-absorbable, water-insoluble polymer that acts as a bile acid-sequestering agent. It is a more recent addition to the class of bile acid-sequestering agents and has a unique structure that allows it to selectively bind to trihydroxy and dihydroxy bile acids. This selectivity contributes to its reduced side effects compared to older agents like cholestyramine and colestipol. Colesevelam does not possess chloride ions and is not an anion-exchange resin. Its affinity for hydroxyl systems enables it to "pick up" water, resulting in softer, gel-like materials that are easier to excrete.

Uses

1. Used in Pharmaceutical Industry:
Colesevelam is used as a bile acid sequestrant for reducing elevated low-density lipoprotein (LDL) cholesterol in patients with primary hyperlipidemia. By binding and blocking bile acids, it compels the removal of LDL cholesterol from the bloodstream into the liver, thus lowering the risk of vascular disease.
2. Used in Diabetes Management:
Colesevelam is used as a treatment to improve glycemic control in patients with type 2 diabetes. Its unique water-absorbing hydrogel formulation allows it to be used as a monotherapy or in combination with statins, producing an additional reduction in LDL-cholesterol levels.
3. Used in Antimicrobial Applications:
Colesevelam is also used for its antibacterial properties, providing an additional layer of health benefits for patients using it for cholesterol and diabetes management.

Originator

GelTex (US)

Clinical Use

#N/A

Drug interactions

Potentially hazardous interactions with other drugs Antidiabetic agents: absorption of glipizide, glibenclamide and glimepiride reduced, administer at least 4 hours before colesevelam; metformin extended release exposure increased, monitor carefully. Ciclosporin: may reduce absorption of ciclosporin. Olmesartan: absorption of olmesartan reduced, administer at least 4 hours before colesevelam.

Metabolism

Not absorbed.

InChI:InChI=1/C13H29N.C12H29N2.C3H5ClO.C3H9N/c1-3-5-6-7-8-9-10-11-13-14-12-4-2;1-5-10-13-11-8-6-7-9-12-14(2,3)4;4-1-3-2-5-3;1-2-3-4/h14H,3-13H2,1-2H3;13H,5-12H2,1-4H3;3H,1-2H2;2-4H2,1H3/q;+1;;