18265-46-8 Usage
Description
D-RIBOSE-5-PHOSPHATE DISODIUM SALT is a white to yellowish crystalline powder or needles that serves as a crucial reagent in the synthesis of nucleotides and nucleic acids. It is an intermediate of the oxidative branch of the Pentose Phosphate Pathway, playing a significant role in various biological processes.
Uses
Used in Biochemical Research:
D-RIBOSE-5-PHOSPHATE DISODIUM SALT is used as a reagent for the synthesis of nucleotides and nucleic acids, which are essential components of DNA and RNA. Its role in the Pentose Phosphate Pathway makes it a vital component in biochemical research and understanding the fundamental processes of life.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, D-RIBOSE-5-PHOSPHATE DISODIUM SALT is used as an intermediate in the production of various drugs and therapeutic agents. Its involvement in the synthesis of nucleotides and nucleic acids makes it a key component in the development of medications targeting genetic disorders and other diseases related to nucleic acid metabolism.
Used in Diagnostic Applications:
D-RIBOSE-5-PHOSPHATE DISODIUM SALT is utilized in diagnostic applications to assess the activity of enzymes involved in the Pentose Phosphate Pathway. By measuring the levels of this compound, researchers and clinicians can gain insights into the metabolic status of a patient and diagnose potential disorders related to nucleic acid metabolism.
Used in Nutritional Supplements:
As a precursor to nucleotides and nucleic acids, D-RIBOSE-5-PHOSPHATE DISODIUM SALT is used in nutritional supplements to support the body's natural production of these essential molecules. This can be particularly beneficial for individuals with certain health conditions or those looking to enhance their overall cellular function and support their immune system.
Check Digit Verification of cas no
The CAS Registry Mumber 18265-46-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,2,6 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18265-46:
(7*1)+(6*8)+(5*2)+(4*6)+(3*5)+(2*4)+(1*6)=118
118 % 10 = 8
So 18265-46-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/p-2/t2-,3-,4-,5-/m1/s1
18265-46-8Relevant articles and documents
ENZYMATIC SYNTHESIS OF PHOSPHORIC MONOESTERS WITH ALKALINE PHOSPHATASE IN REVERSE HYDROLYSIS CONDITIONS
Pradines, A.,Klaebe, A.,Perie, J.,Paul, F.,Monsan, P.
, p. 6373 - 6386 (1988)
Title compounds were synthesized on a preparative scale using alkaline phosphatase, orthophosphoric monoester phosphohydrolase E.C. 3.1.3.1., in reverse hydrolysis conditions.Optimization for one of the 25 phosphoryl acceptors investigated (glycerol) shows that up to 55percent synthesis yield can be obtained using a large excess of substrate, conditions in which the enzymatic activity remains high.From the results obtained with different phosphoryl group donors, phosphate, pyrophosphate and polyphosphates and with enzymes of different sources, it comes up that the best results are obtained with pyrophosphate and with the weakly purified calf intestine alkaline phosphatase.The extent of enzymatic hydrolysis of the donor can be reduced owing to the existence of two different pH optima for the two reactions, phosphorylation and hydrolysis.The synthesis can be also performed using inert co-solvents which allow to reduce the amount of acceptor used, as long as Zn++ is added to the reaction medium.The results are discussed in terms of the catalytic mechanism of alkaline phosphatase.
