1822-00-0 Usage
Description
(TRIMETHYLSILYL)METHYLLITHIUM is a clear light yellow liquid with a melting point of 112 °C. It is a reagent used in various chemical reactions, including the methylenation of carbonyl compounds, synthesis of allylsilanes, and reactions with carboxylic acid derivatives.
Uses
Used in Chemical Synthesis:
(TRIMETHYLSILYL)METHYLLITHIUM is used as a reagent for the methylenation of carbonyl compounds, which is essential for the synthesis of various organic compounds. It also reacts with carboxylic acid derivatives to provide α-silyl ketones, contributing to the formation of complex organic molecules.
Used in Polymerization and Copolymerization:
(TRIMETHYLSILYL)METHYLLITHIUM initiates the polymerization and copolymerization of cyclosiloxanes, which are important for the production of silicone-based materials with various applications in industries such as electronics, automotive, and construction.
Used in Metal Complex Alkylation:
(TRIMETHYLSILYL)METHYLLITHIUM is used as an alkylating agent for metal complexes, which can improve the properties of these complexes and enhance their performance in various applications, such as catalysis and materials science.
Used in Peterson Alkenation:
(TRIMETHYLSILYL)METHYLLITHIUM participates in the Peterson Alkenation reaction, which is a method for the synthesis of alkenes from alkyl halides and aldehydes. This reaction is useful for the preparation of various unsaturated organic compounds.
Used in Reactions with Other Electrophiles:
(TRIMETHYLSILYL)METHYLLITHIUM can also react with other electrophiles, making it a versatile reagent in organic synthesis for the formation of different types of chemical bonds and structures.
Preparation
Trimethylsilylmethyllithium is obtained by reaction of (chloromethyl)-
trimethylsilane with lithium metal in an inert solvent. It is
also available by displacement of a heteroatom group based on
sulfur, silicon, or tin.
Check Digit Verification of cas no
The CAS Registry Mumber 1822-00-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,2 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1822-00:
(6*1)+(5*8)+(4*2)+(3*2)+(2*0)+(1*0)=60
60 % 10 = 0
So 1822-00-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H11Si.Li/c1-5(2,3)4;/h1H2,2-4H3;/rC4H11LiSi/c1-6(2,3)4-5/h4H2,1-3H3
1822-00-0Relevant articles and documents
A Convenient Two-Step Preparation of Monodeuteriated Tetramethylsilane
Saljoughian, Manouchehr
, p. 519 - 522 (1984)
Purified partially mono-deuteriated TMS was synthesized by preparing lithiomethyltrimethylsilane from chloromethyltrimethylsilane and reaction of the former with deuteriated water.Using this reference deuterium chemical shifts in parts per million can be
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Sommer et al.
, p. 3765 (1953)
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USING ALKYLMETAL REAGENTS FOR DIRECTED METALATION OF AZAAROMATICS
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Page 9-10, (2010/02/09)
Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle compounds.
Non-steroid progesterone receptor agonist and antagonist and compounds and methods
-
, (2008/06/13)
Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.