18067-07-7Relevant articles and documents
Carbonyl technetium-99mm marked melphalan complex as well as preparation method and application thereof
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Paragraph 0035-0036, (2018/02/04)
The invention discloses a carbonyl technetium-99mm marked melphalan complex as well as a preparation method and application thereof. The preparation method of the carbonyl technetium-99mm marked melphalan complex comprises the following steps of: deriving a new ligand IDA-EtMFL from melphalan molecule; and enabling the ligand to react with an intermediate [99mTc(CO)3(H2O)3] to obtain the carbonyl technetium-99mm marked melphalan complex. The carbonyl technetium-99mm marked melphalan complex disclosed by the invention has good tumor uptake and retention and good tumor/muscle ratio and can be applied to the SPECT imaging diagnosis of tumor.