17738-71-5

Basic information

• Product Name: (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID
• Synonyms: Aceticacid, [(4-chlorophenyl)amino]oxo- (9CI); Oxanilic acid, 4'-chloro- (8CI);4'-Chlorooxanilic acid; N-(4-Chlorophenyl)oxamic acid; p-Chlorooxanilic acid
• CAS NO: 17738-71-5
• Molecular Formula: C₈H₆ClNO₃
• Molecular Weight: 199.59114
• Mol File: 17738-71-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.546g/cm³
• CAS DataBase Reference: (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID(17738-71-5)
• EPA Substance Registry System: (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID(17738-71-5)

Safety Data

• Hazardous Substances Data: 17738-71-5(Hazardous Substances Data)

Usage

Description

(4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID, also known as N-Chloroacetyl-4-aminobenzoic acid or N-chloroacetyl-p-aminobenzoic acid, is a chemical compound with the molecular formula C8H7ClNO3. It is a derivative of p-aminobenzoic acid, featuring an additional acetyl group and a chlorine atom attached to the amino group. This white to off-white crystalline powder has been synthesized for potential applications in the pharmaceutical industry and the production of dyes and pigments. However, it is also a known irritant to the skin, eyes, and respiratory system, and is suspected to be an environmental toxin with potential harmful effects on aquatic life if released into water systems.

Uses

Used in Pharmaceutical Industry:
(4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows it to serve as a building block in the development of new medications, potentially contributing to advancements in healthcare.
Used in Dye and Pigment Production:
In the chemical industry, (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID is utilized in the production of dyes and pigments. Its chemical properties make it a valuable component in the creation of a wide range of colorants used in various applications, from textiles to plastics.
Used in Environmental Research:
Given its suspected environmental toxicity, (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID is also used in environmental research to study its potential impact on aquatic life and ecosystems. This research can help in the development of strategies to mitigate its harmful effects and ensure the safety of water systems.

InChI:InChI=1/C8H6ClNO3/c9-5-1-3-6(4-2-5)10-7(11)8(12)13/h1-4H,(H,10,11)(H,12,13)/p-1

Upstream product

• 17722-17-7 N-(4-chlorophenyl)-2-cyanoacetamide 
• 17118-74-0 ethyl oxalylchloride 
• 106-47-8 4-chloro-aniline 
• 4755-77-5 Ethyl oxalyl chloride 
• 5397-14-8 ethyl 2-[(4-chlorophenyl)amino]-2-oxoacetate 
• 41374-66-7 methyl 2-[(4-chlorophenyl)amino]-2-oxoacetate 

Downstream Products

• 1040763-02-7 C₂₁H₁₁BrCl₂F₃N₃O₃ 
• 13142-10-4 1-(4-bromophenyl)-3-(4-chlorophenyl)urea 
• 13208-51-0 3-(4-chlorophenyl)-1-(phenylmethyl)urea 
• 13208-64-5 1-(4-chlorophenyl)-3-propylurea 

Relevant articles and documents

Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors

Several small molecule CD4 mimics, which inhibit the interaction of gp120 with CD4, have been developed. Original CD4 mimics such as NBD-556, which has an aromatic ring, an oxalamide linker and a piperidine moiety, possess significant anti-HIV activity bu

Direct C-H Functionalization of Phenanthrolines: Metal- And Light-Free Dicarbamoylations

A direct method for C-H dicarbamoylations of phenanthrolines has been developed, which is capable of directly installing primary, secondary as well as tertiary amides. This is a significant improvement on the previous direct method, which was limited to primary amides. The metal-, light-, and catalyst-free Minisci-type reaction is cheap, operationally simple, and scalable. We demonstrate that the step efficiency toward dicarbamoylated phenanthroline targets can now be significantly improved.

POLYCYCLIC COMPOUND ACTING AS IDO INHIBITOR AND/OR IDO-HDAC DUAL INHIBITOR

The present invention provides polycyclic compounds as IDO inhibitors and/or dual inhibitors of IDO-HDAC. Specifically, the present invention provides compounds represented by the following formula (I), wherein each group is defined as described in the specification. The compounds have IDO inhibitory activity or IDO-HDAC dual inhibitory activity and can be used for preventing or treating diseases associated with IDO and/or IDO-HDAC activity or expression levels. At the same time, the compounds of the present invention can be combined with an antitumor antibody such as PD-1 and PD-L1, and such a combination can greatly increase the antitumor response rate of the antibody and broaden the types of tumors to be treated.